Release Time:2023-01-29  Hits:

Date of Publication: 2022-10-09

Journal: 化工学报

Issue: 3

Page Number: 964-969

ISSN: 0438-1157

Abstract: Oscillation phenomenon is an inherent characteristic in biological systems and plays an important role in many dynamic bioprocesses. In order to explore the certain conditons that could possibly boost a oscillation, the metabolic pathway of theSaccharomyces cerevisiae, glycolysis were researched, and the parameters of mathmatical model was analyzed. Firstly, the simulation results associated the phase diagrams indicated that the model exists sustained oscillations with constant amplitude (limit cycle oscillations). Next, bifurcation analysis approach was used to investigate the infulence of parameters for the system producing oscillations. The results showed that several parameters of the model could lead to oscillations and the range of parameters' value was obtained, which could be applied to direct the manipulation of metabolic oscillations.

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