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个人信息Personal Information
教授
博士生导师
硕士生导师
主要任职：Director, State Key laboratory of Fine Chemicals
其他任职：精细化工国家重点实验室主任、国务院学科评议组成员
性别：男
毕业院校：大连理工大学
学位：博士
所在单位：化工学院
学科：应用化学. 精细化工. 化学生物学
办公地点：大连理工大学精细化工国家重点实验室
西部校区化工实验楼F-202#
http://peng-group.dlut.edu.cn/
联系方式：大连理工大学精细化工国家重点实验室 西部校区化工实验楼F-202 辽宁省大连市高新区凌工路2号，大连116024 Tel: 0411-84986306; Fax: 0411-84986292；课题组网址：http://peng-group.dlut.edu.cn/
电子邮箱：pengxj@dlut.edu.cn
A proton-activatable aminated-chrysophanol sensitizer for photodynamic therapy
点击次数：
论文类型：期刊论文
发表时间：2017-12-01
发表刊物：DYES AND PIGMENTS
收录刊物：Scopus、SCIE、EI
卷号：147
页面范围：476-483
ISSN号：0143-7208
关键字：Chrysophanol; Proton-activatable; Photosensitiser; Lysosomes; Anthraquinone dye
摘要：Exploiting the tumor microenvironment provides a new strategy for cancer treatment. In order to develop the microenvironment-selective photosensitiser, we rationally designed a proton-activatable aminated-chrysophanol derivative-compound 3, which combines fluorescence and reactive oxygen species regulated by the tumor acidic microenvironment for the first time. Furthermore, two PET tertiary amine substituents introduced by compound 3 enhance the cellular uptake, prolong the wavelength of the absorption, and increase the phototoxicity. Not only can compound 3 distinguish the cancer cells from normal cells but also the tumor from the normal tissue by the higher fluorescence intensity in cancer cells and tissues. Additionally, lysosome destruction test proves cell necrosis in lysosomal related pathway. We believe that the proton-activatable photosensitiser modulated by tumor acidic microenvironment offers a good chance for the cancer treatment in clinic. (C) 2017 Elsevier Ltd. All rights reserved.