|
个人信息Personal Information
教授
博士生导师
硕士生导师
主要任职：Director, State Key laboratory of Fine Chemicals
其他任职：精细化工国家重点实验室主任、国务院学科评议组成员
性别：男
毕业院校：大连理工大学
学位：博士
所在单位：化工学院
学科：应用化学. 精细化工. 化学生物学
办公地点：大连理工大学精细化工国家重点实验室
西部校区化工实验楼F-202#
http://peng-group.dlut.edu.cn/
联系方式：大连理工大学精细化工国家重点实验室 西部校区化工实验楼F-202 辽宁省大连市高新区凌工路2号，大连116024 Tel: 0411-84986306; Fax: 0411-84986292；课题组网址：http://peng-group.dlut.edu.cn/
电子邮箱：pengxj@dlut.edu.cn
A lysosome-targeted BODIPY as potential NIR photosensitizer for photodynamic therapy
点击次数：
论文类型：期刊论文
发表时间：2017-12-01
发表刊物：DYES AND PIGMENTS
收录刊物：Scopus、SCIE、EI
卷号：147
页面范围：99-105
ISSN号：0143-7208
关键字：BODIPY; Photosensitizer; Targeting; Lysosomes; Photodynamic therapy
摘要：As an indispensable organelle, lysosomes play critical role in cell digestion and are closely relate to cell death and apoptosis. Photosensitizers that target to lysosomes are extremely important to photodynamic therapy. Herein, we report an excellent BODIPY based photosensitizer MBDP for lysosome targeting NIR photosensitizer. MBDP exhibits excellent PDT efficiency with low IC50 of 0.2 mu M compared to the classical photosensitizer Ce6 (IC50 = 139 mu M). Furthermore, MBDP can localize in lysosomes of cancer cells and produce significant singlet oxygen with photoexcitation of 660 nm red light. Additionally, lysosome destruction test and photoinduce cell death assay demonstrate that MBDP-mediated PDT is able to damage the lysosome integrity severely and result in cell apoptosis and death in lysosomal related pathway. (C) 2017 Elsevier Ltd. All rights reserved.