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个人信息Personal Information
教授
博士生导师
硕士生导师
主要任职：Director, State Key laboratory of Fine Chemicals
其他任职：精细化工国家重点实验室主任、国务院学科评议组成员
性别：男
毕业院校：大连理工大学
学位：博士
所在单位：化工学院
学科：应用化学. 精细化工. 化学生物学
办公地点：大连理工大学精细化工国家重点实验室
西部校区化工实验楼F-202#
http://peng-group.dlut.edu.cn/
联系方式：大连理工大学精细化工国家重点实验室 西部校区化工实验楼F-202 辽宁省大连市高新区凌工路2号，大连116024 Tel: 0411-84986306; Fax: 0411-84986292；课题组网址：http://peng-group.dlut.edu.cn/
电子邮箱：pengxj@dlut.edu.cn
Bromo-pentamethine as mitochondria-targeted photosensitizers for cancer cell apoptosis with high efficiency
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论文类型：期刊论文
发表时间：2018-02-01
发表刊物：DYES AND PIGMENTS
收录刊物：SCIE、EI
卷号：149
页面范围：633-638
ISSN号：0143-7208
关键字：Cyanine dye; Mitochondria; Photosensitizer; Photodynamic therapy; Cancer cell; Apoptosis
摘要：Mitochondria play essential roles in cellular energy supply and produce 90% of reactive oxygen species. A mitochondrial targeted photosensitizer is greatly beneficial to improve the photodynamic therapeutic effect via apoptosis. Herein bromo-pentamethine dyes (lambda(abs) > 650 nm) are designed as mitochondria-localized anticancer photosensitizers. Cell experiments demonstrate that Cy-Br localizes in mitochondria with very low cytotoxicity in dark, and induces cancer cells apoptosis under light with IC50 as low as 62 nM, much better than commercial Ce6 (3706 nM). Bromo-group could enhance the quantum yield of reactive oxygen species. The high efficiency might provide a new clue to develop new photosensitizers.