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个人信息Personal Information
教授
博士生导师
硕士生导师
主要任职：Director, State Key laboratory of Fine Chemicals
其他任职：精细化工国家重点实验室主任、国务院学科评议组成员
性别：男
毕业院校：大连理工大学
学位：博士
所在单位：化工学院
学科：应用化学. 精细化工. 化学生物学
办公地点：大连理工大学精细化工国家重点实验室
西部校区化工实验楼F-202#
http://peng-group.dlut.edu.cn/
联系方式：大连理工大学精细化工国家重点实验室 西部校区化工实验楼F-202 辽宁省大连市高新区凌工路2号，大连116024 Tel: 0411-84986306; Fax: 0411-84986292；课题组网址：http://peng-group.dlut.edu.cn/
电子邮箱：pengxj@dlut.edu.cn
A novel fluorescent probe for the ratiometric recognition of protein based on intramolecular charge transfer
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论文类型：期刊论文
发表时间：2018-07-15
发表刊物：SENSORS AND ACTUATORS B-CHEMICAL
收录刊物：SCIE、EI
卷号：265
页面范围：204-210
ISSN号：0925-4005
关键字：Fluorescent recognition; Intramolecular charge transfer (ICT); Serum albumin recognition; Ratiometric identification
摘要：The quantitative recognition of proteins receives great importance in the fields of biology and biomedicine. Though the ratiometric fluorescent probe is a good choice for the quantitative recognition which is less susceptible to the environmental and instrumental interference, very few examples have been reported in the protein identification. In this work, a novel and interesting probe, MY, was developed for the quantitative recognition of serum albumin based on the intramolecular charge transfer (ICT) mechanism. By the structure regulation, the distribution between ICT and twisted ICT state was well controlled. The MY showed a fast, sensitive, and ratiometric response to the serum albumin. Besides, the accurate recognition of serum albumin in practical samples exhibited good recoveries compared with the bromocresol green-based standard method. (C) 2018 Elsevier B.V. All rights reserved.