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个人信息Personal Information
教授
博士生导师
硕士生导师
主要任职：中国化学会创始会士、常务理事，中国化工学会会士
性别：男
毕业院校：大连理工大学
学位：博士
所在单位：化工学院
学科：应用化学. 精细化工. 化学生物学
办公地点：大连理工大学西部校区知顺楼F-202#
http://peng-group.dlut.edu.cn/
联系方式：大连理工大学西部校区知顺楼F-202 辽宁省大连市高新区凌工路2号，大连116024 课题组网址：http://peng-group.dlut.edu.cn/ E-mail: pengxj@dlut.edu.cn
电子邮箱：pengxj@dlut.edu.cn
Fluorescence ratiometry and fluorescence lifetime (FLIM) imaging: Dual mode imaging cellular viscosity by a single molecular rotor
点击次数：
论文类型：会议论文
发表时间：2011-12-03
收录刊物：EI、Scopus
摘要：Intracellular viscosity strongly influences transportation of mass and signal, interactions between the biomacromolecules, and diffusion of reactive metabolites in live cells such as ROS and RNS. Intracellular viscosity changes relate to a number of diseases and pathologies. So it is meaningful to investigate the microviscosity at cellular level. Fluorescent molecular rotors are recently developed sensors used to determine the environmental viscosity. Due to the complexity of live cells, it is important to carry out the viscosity determinations in multimode for high reliability and accuracy. The first molecular rotor (RY) capable of dual mode fluorescence imaging (ratiometry imaging and fluorescence lifetime imaging) of intracellular viscosity is reported. ? 2011 IEEE.