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个人信息Personal Information
教授
博士生导师
硕士生导师
主要任职：Director, State Key laboratory of Fine Chemicals
其他任职：精细化工国家重点实验室主任、国务院学科评议组成员
性别：男
毕业院校：大连理工大学
学位：博士
所在单位：化工学院
学科：应用化学. 精细化工. 化学生物学
办公地点：大连理工大学精细化工国家重点实验室
西部校区化工实验楼F-202#
http://peng-group.dlut.edu.cn/
联系方式：大连理工大学精细化工国家重点实验室 西部校区化工实验楼F-202 辽宁省大连市高新区凌工路2号，大连116024 Tel: 0411-84986306; Fax: 0411-84986292；课题组网址：http://peng-group.dlut.edu.cn/
电子邮箱：pengxj@dlut.edu.cn
Selective imaging of Co2+ in live cells with a "turn-on" fluorescent probe
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论文类型：期刊论文
发表时间：2017-02-01
发表刊物：SENSORS AND ACTUATORS B-CHEMICAL
收录刊物：SCIE、EI、Scopus
卷号：239
页面范围：1237-1242
ISSN号：0925-4005
关键字：Fluorescence; High selectivity; pH independent; Cobalt ions; Live cells
摘要：Co2+ fluorescent probes have been scarcely developed in recent years because it is difficult to selectively sense cobalt ions in presence of competitive divalent ions. Herein, is an account of synthesis and characterization of reasonably designed turn-on fluorescent probe SGPB1 with Salicylhydrazide as binding site based on BODIPY adapted fluorophore. It was capable to operate in CHEF mechanism toward Co2+ and showed high sensitivity and remarkable selectivity for Co2+ with 10-fold fluorescence enhancement. Furthermore, cell imaging experiments proved that SGPB1 was suitable for detecting Co2+ in biological environment. (C) 2016 Elsevier B.V. All rights reserved.