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个人信息Personal Information
教授
博士生导师
硕士生导师
主要任职：Director, State Key laboratory of Fine Chemicals
其他任职：精细化工国家重点实验室主任、国务院学科评议组成员
性别：男
毕业院校：大连理工大学
学位：博士
所在单位：化工学院
学科：应用化学. 精细化工. 化学生物学
办公地点：大连理工大学精细化工国家重点实验室
西部校区化工实验楼F-202#
http://peng-group.dlut.edu.cn/
联系方式：大连理工大学精细化工国家重点实验室 西部校区化工实验楼F-202 辽宁省大连市高新区凌工路2号，大连116024 Tel: 0411-84986306; Fax: 0411-84986292；课题组网址：http://peng-group.dlut.edu.cn/
电子邮箱：pengxj@dlut.edu.cn
Synthesis of a stationary phase based on silica modified with branched octadecyl groups by Michael addition and photoinduced thiol-yne click chemistry for the separation of basic compounds
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论文类型：期刊论文
发表时间：2016-04-01
发表刊物：JOURNAL OF SEPARATION SCIENCE
收录刊物：SCIE、EI、PubMed
卷号：39
期号：8
页面范围：1461-1470
ISSN号：1615-9306
关键字：Basic compounds; High-performance liquid chromatography; Michael addition; Stationary phases; Thiol-yne click chemistry
摘要：A novel silica-based stationary phase with branched octadecyl groups was prepared by the sequential employment of the Michael addition reaction and photoinduced thiol-yne click chemistry with 3-aminopropyl-functionalized silicamicrospheres as the initialmaterial. The resulting stationary phase denoted as SiO2-N(C18)(4) was characterized by elemental analysis, FTIR spectroscopy and Raman spectroscopy, demonstrating the existence of branched octadecyl groups in silicamicrospheres. The separations of benzene homologous compounds, acid compounds and amine analogues were conducted, demonstratingmixed-mode separation mechanism on SiO2-N(C18)(4). Baseline separation of basic drugs mixture was acquired with the mobile phase of acetonitrile/H2O (5%, v/v). SiO2-N(C18)(4) was further applied to separate Corydalis yanhusuo Wang water extracts, and more baseline separation peaks were obtained for SiO2-N(C18)(4) than those on Atlantis dC18 column. It can be expected that this new silica-based stationary phase will exhibit great potential in the analysis of basic compounds.