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论文类型：期刊论文

发表时间：2019-11-01

发表刊物：DYES AND PIGMENTS

收录刊物：SCIE、EI

卷号：170

ISSN号：0143-7208

关键字：Benzo[a]phenoselenazinium; Photosensitizer; Tumor-targeting; Lysosomes; Photodynamic therapy

摘要：The ultimate goal of cancer therapy is to develop antitumor agents that will destroy selectively tumor cells while sparing the health cell of the patient. Herein, we reported a novel tumor-specific and lysosome dual-targeted NIR photosensitizer, Se-Biotin, by conjugating a biotin ligand into benzo[a]phenoselenazinium derivative dye for selective destruction of tumor cells. Attractively, co-culture model showed that Se-Biotin could selectively target to and retain in biotin receptor-overexpressed tumor cells, which as a result significantly minimized the side effects toward normal cells. As confinned by the in vitro anticancer mechanism, after cellular internalization, upon irradiation, the effective O-1(2) generation (Phi(Delta) = 0.69)severely disrupted the lysosomalintegrity and subsequently led to apoptotic cell death. Benefiting from these merits, Se-Biotin successfully achieved a superior anticancer performance with the IC50 as low as 85 nM, only under a low light dose irradiation (12 J/cm(2), 660 nm). Therefore, these result demonstrated that Se-Biotin will be a promising PDT agent for targeted cancer photodynamic therapy.