|
个人信息Personal Information
教授
博士生导师
硕士生导师
主要任职：Director, State Key laboratory of Fine Chemicals
其他任职：精细化工国家重点实验室主任、国务院学科评议组成员
性别：男
毕业院校：大连理工大学
学位：博士
所在单位：化工学院
学科：应用化学. 精细化工. 化学生物学
办公地点：大连理工大学精细化工国家重点实验室
西部校区化工实验楼F-202#
http://peng-group.dlut.edu.cn/
联系方式：大连理工大学精细化工国家重点实验室 西部校区化工实验楼F-202 辽宁省大连市高新区凌工路2号，大连116024 Tel: 0411-84986306; Fax: 0411-84986292；课题组网址：http://peng-group.dlut.edu.cn/
电子邮箱：pengxj@dlut.edu.cn
Synergistic Anticancer Therapy by Ovalbumin Encapsulation-Enabled Tandem Reactive Oxygen Species Generation
点击次数：
论文类型：期刊论文
发表时间：2021-04-12
发表刊物：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷号：59
期号：45
页面范围：20008-20016
ISSN号：1433-7851
关键字：cisplatin; Fenton reactions; hypoxic; photodynamic therapy; synergistic
摘要：The anticancer efficacy of photodynamic therapy (PDT) is limited due to the hypoxic features of solid tumors. We report synergistic PDT/chemotherapy with integrated tandem Fenton reactions mediated by ovalbumin encapsulation for improved in vivo anticancer therapy via an enhanced reactive oxygen species (ROS) generation mechanism. O(2)(.-)produced by the PDT is converted to H(2)O(2)by superoxide dismutase, followed by the transformation of H(2)O(2)to the highly toxic(.)OH via Fenton reactions by Fe(2+)originating from the dissolution of co-loaded Fe(3)O(4)nanoparticles. The PDT process further facilitates the endosomal/lysosomal escape of the active agents and enhances their intracellular delivery to the nucleus-even for drug-resistant cells. Cisplatin generates O(2)(.-)in the presence of nicotinamide adenine dinucleotide phosphate oxidase and thereby improves the treatment efficiency by serving as an additional O(2)(.-)source for production of(.)OH radicals. Improved anticancer efficiency is achieved under both hypoxic and normoxic conditions.