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个人信息Personal Information
教授
博士生导师
硕士生导师
主要任职：Director, State Key laboratory of Fine Chemicals
其他任职：精细化工国家重点实验室主任、国务院学科评议组成员
性别：男
毕业院校：大连理工大学
学位：博士
所在单位：化工学院
学科：应用化学. 精细化工. 化学生物学
办公地点：大连理工大学精细化工国家重点实验室
西部校区化工实验楼F-202#
http://peng-group.dlut.edu.cn/
联系方式：大连理工大学精细化工国家重点实验室 西部校区化工实验楼F-202 辽宁省大连市高新区凌工路2号，大连116024 Tel: 0411-84986306; Fax: 0411-84986292；课题组网址：http://peng-group.dlut.edu.cn/
电子邮箱：pengxj@dlut.edu.cn
A facile AIEgen-based fluorescent probe design strategy and its application in hypochlorite probe construction
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论文类型：期刊论文
发表时间：2021-04-12
发表刊物：SENSORS AND ACTUATORS B-CHEMICAL
卷号：314
关键字：Design strategy; Hypochlorite probe; Aggregation-induced emission; Portable test strips; Cell imaging
摘要：Fluorogens with aggregation-induced emission (AIE) characteristics (AIEgens) and the strategy for constructing AIEgen-based fluorescent probes have attracted extensive attention. In this work, inspired by the relationship between chemical structures and fluorescence properties of three tetraphenylethylene (TPE)-based compounds, a facile strategy by modifying of AIEgen with electron-donating substituent (EDS) and electron-withdrawing substituent (EWS) capable of reacting with target for fluorescent probe design was proposed. Under the guidance, a series of hypochlorite (ClO-) probes named TPEP-CN, TPEP-NO2, M-TPEP-CN and M-TPEP-NO2 were rationally designed and synthesized, and their sensing performances were studied. Finally, M-TPEP-CN with the most obvious fluorescence color change from orange to green in the presence of ClO- was selected, and then successfully applied to ClO- detection in aqueous solution as well as the construction of portable test strips and cell imaging, which confidently proved the feasibility of our probe design strategy and more excellent probes will be developed according to this strategy in the future.