|
个人信息Personal Information
教授
博士生导师
硕士生导师
主要任职：Director, State Key laboratory of Fine Chemicals
其他任职：精细化工国家重点实验室主任、国务院学科评议组成员
性别：男
毕业院校：大连理工大学
学位：博士
所在单位：化工学院
学科：应用化学. 精细化工. 化学生物学
办公地点：大连理工大学精细化工国家重点实验室
西部校区化工实验楼F-202#
http://peng-group.dlut.edu.cn/
联系方式：大连理工大学精细化工国家重点实验室 西部校区化工实验楼F-202 辽宁省大连市高新区凌工路2号，大连116024 Tel: 0411-84986306; Fax: 0411-84986292；课题组网址：http://peng-group.dlut.edu.cn/
电子邮箱：pengxj@dlut.edu.cn
Near-Infrared Chemiluminescent Probe for Real-Time Monitoring Singlet Oxygen in Cells and Mice Model
点击次数：
论文类型：期刊论文
发表时间：2021-02-02
发表刊物：ACS SENSORS
卷号：5
期号：10
页面范围：3158-3164
ISSN号：2379-3694
关键字：singlet oxygen; chemiluminescence imaging; near-infrared; photodynamic therapy; phototoxicity; mice model
摘要：Singlet oxygen (O-1(2)) plays a vital role in metabolism. However, because of its extremely high reactivity and short-lived state, the in vivo detection of O-1(2) is challenging. To address this issue, for the first time, we herein constructed a near-infrared (NIR) chemiluminescent probe (CL-SO) by caging the precursor of phenoxy-dioxetane scaffolds and a dicyanomethyl-chromone acceptor for selective O-1(2) detection. This probe can detect (1)O(2 )in vitro with a tremendous turn-on chemiluminescence signal in the NIR region (700 nm) and image intracellular O-1(2) produced by the photosensitizer during the simulated action of photodynamic therapy (PDT). Notably, (1)O(2 )level changes in the abdominal cavity and tumor of the various mice model under different stimulations and PDT action were effectively monitored by CL-SO, providing a novel chemiluminescence imaging platform to explore O-1(2) generation in PDT-associated applications.