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个人信息Personal Information
教授
博士生导师
硕士生导师
主要任职：中国化学会创始会士、常务理事，中国化工学会会士
性别：男
毕业院校：大连理工大学
学位：博士
所在单位：化工学院
学科：应用化学. 精细化工. 化学生物学
办公地点：大连理工大学西部校区知顺楼F-202#
http://peng-group.dlut.edu.cn/
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Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells
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论文类型：期刊论文
发表时间：2011-02-21
发表刊物：ORGANIC & BIOMOLECULAR CHEMISTRY
收录刊物：Scopus、PubMed、EI、SCIE
卷号：9
期号：4
页面范围：980-983
ISSN号：1477-0520
摘要：A novel molecule T1 with efficient intramolecular charge transfer was designed as a fluorescent chemodosimeter for cysteine (Cys) and homocysteine (Hcy). Upon addition of Cys/Hcy, T1 exhibited greatly enhanced fluorescence intensity as well as a large absorption peak shift (70 nm), and can be used for bioimaging of Cys/Hcy in living cells and detection in human plasma by visual color change. The detection mechanism was proved by (1)H NMR, mass spectrometry analysis and Gaussian calculations.