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个人信息Personal Information
教授
博士生导师
硕士生导师
主要任职：中国化学会创始会士、常务理事，中国化工学会会士
性别：男
毕业院校：大连理工大学
学位：博士
所在单位：化工学院
学科：应用化学. 精细化工. 化学生物学
办公地点：大连理工大学西部校区知顺楼F-202#
http://peng-group.dlut.edu.cn/
联系方式：大连理工大学西部校区知顺楼F-202 辽宁省大连市高新区凌工路2号，大连116024 课题组网址：http://peng-group.dlut.edu.cn/ E-mail: pengxj@dlut.edu.cn
电子邮箱：pengxj@dlut.edu.cn
Synthesis and DNA photocleavage study of Ru(bpy)(3)(2+)-(CH2)(n)-MV2+ complexes
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论文类型：期刊论文
发表时间：2010-05-14
发表刊物：DALTON TRANSACTIONS
收录刊物：SCIE、EI、PubMed
卷号：39
期号：18
页面范围：4411-4416
ISSN号：1477-9226
摘要：A series of Ru(bpy)(3)(2+)-(CH2)(n)-MV2+ complexes (1, n = 3, 4, 7) used for DNA photocleavage have been designed and synthesized. Under the irradiation of visible light, complexes 1 can cleave supercoiled plasmid DNA (pBR322) both in air and under Ar atmosphere. Radical species such as O2(-center dot), (OH)-O-center dot and the light-induced charge-separated (CS) oxidation state Ru(bpy)(3)(3+)-(CH2)(n)-MV+center dot are responsible for the cleavage. The longer the carbon chain linkage, the higher the DNA photocleavage efficiency. It is noted that backwards intramolecular electron transfer (ET) that exist in complexes 1 can lead to some decreasing effect on the cleavage result, while inclusion of complexes 1 with cucurbit[8]uril (CB[8]) inhibits the backwards ET to some extent, thereby increasing photocleavage efficiency.