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论文类型：期刊论文

发表时间：2011-06-01

发表刊物：MOLECULAR BIOLOGY REPORTS

收录刊物：SCIE

卷号：38

期号：5

页面范围：3561-3567

ISSN号：0301-4851

关键字：Aucubin; Hydrogen peroxide; Apoptosis; PC12 cells; Bcl-2 family

摘要：In this study, the effect of aucubin on H2O2-induced apoptosis was studied by using a rat pheochromocytoma (PC12) cell line. We have analyzed the apoptosis of H2O2-induced PC12 cells, H2O2-induced apoptosis appeared to correlate with lower Bcl-2 expression, higher Bax expression and sequential activation of caspase-3 leading to cleavage of poly-ADP-ribose polymerase (PARP). Aucubin not only inhibited lower Bcl-2 expression, high Bax expression, but also modulated caspase-3 activation, PARP cleavage, and eventually protected against H2O2-induced apoptosis. These results indicated that aucubin can obstruct H2O2-induced apoptosis by regulating of the expression of Bcl-2 and Bax, as well as suppression of caspases cascade activation.