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Indexed by:期刊论文

Date of Publication:2012-10-28

Journal:CANCER LETTERS

Included Journals:SCIE、Scopus

Volume:323

Issue:2

Page Number:180-187

ISSN No.:0304-3835

Key Words:Autophagy; ER stress; BH3 mimetic; Bcl-2

Abstract:Previous results showed that a novel BH3 mimetic S1 could induce cell death in a wide range of cancer types in vitro through Bax/Bak-dependent apoptosis. We demonstrated that in addition to mitochondrial pathway apoptosis, endoplasmic reticulum (ER) stress-associated apoptosis was also induced by Si. Moreover, S1 can induce autophagy in U251 cells, which may occur through ER stress and disruption of the association of Bcl-2 and Beclin 1. Inhibition of autophagy by the autophagic inhibitors 3-methyladenine (3-MA) or chloroquine (CQ) increased S1-induced apoptosis. In conclusion, autophagy plays an important role in S1-induced U251 cell death. (c) 2012 Elsevier Ireland Ltd. All rights reserved.