Release Time:2019-03-09  Hits:

Indexed by: Journal Article

Date of Publication: 2012-10-28

Journal: CANCER LETTERS

Included Journals: Scopus、SCIE

Volume: 323

Issue: 2

Page Number: 180-187

ISSN: 0304-3835

Key Words: Autophagy; ER stress; BH3 mimetic; Bcl-2

Abstract: Previous results showed that a novel BH3 mimetic S1 could induce cell death in a wide range of cancer types in vitro through Bax/Bak-dependent apoptosis. We demonstrated that in addition to mitochondrial pathway apoptosis, endoplasmic reticulum (ER) stress-associated apoptosis was also induced by Si. Moreover, S1 can induce autophagy in U251 cells, which may occur through ER stress and disruption of the association of Bcl-2 and Beclin 1. Inhibition of autophagy by the autophagic inhibitors 3-methyladenine (3-MA) or chloroquine (CQ) increased S1-induced apoptosis. In conclusion, autophagy plays an important role in S1-induced U251 cell death. (c) 2012 Elsevier Ireland Ltd. All rights reserved.