Personal Information
Professor Supervisor of Doctorate Candidates Supervisor of Master's Candidates
Scientific Research
Research Field
1. Bcl-2 inhibitors as target anti-tumor drug
2. Bcl-2 pathway
Paper Publications
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- Zhang Zhichao.Wang, Yuanyuan,Song, Ting,Gao, Jin,Wu, Guiye,Zhang, Jing,Qian, Xuhong.DNA Double Helix Unwinding Triggers Transcription Block-Dependent Apoptosis: A Semiquantitative Probe of the Response of ATM, RNAPII, and p53 to Two DNA Intercalators[J],CHEMICAL RESEARCH IN TOXICOLOGY,2021,22(3):483-491
- 王紫千.Ting Song,Zhang Zhichao.Targeting the allosteric pathway that interconnect the core-functional scaffold and the distal phosphorylation sites for specific dephosphorylation of Bcl-2.[J],Journal of medicinal chemistry,2021,63(1111):13733-13744
- Zhang Zhichao.张肖冬,王紫千.A “three-in-one” multi-functional probe for Bcl-2/Mcl-1 profiling and visualizing in situ.[J],ChemBioChem,2021,22:326-329
- Zhu Junjie.Song Ting,Guo Yafei,Ji Tong,Zhang Zhichao,Wang Ziqian,Guo Zongwei,Zhang Xiaodong.Structure-based design, synthesis, and evaluation of Bcl-2/Mcl-1 dual inhibitors[J],Archiv der Pharmazie,2020,353(5):e2000005
- 张志超.Affinity-based probe reveal Bim negatively regulates the chaperone functions of Hsp70, a non-Bcl-2 BH3 receptor..[A],2019,(13 Supplement): 79:2754-
- 郭宗伟.刘朋,张民行,张肖冬,张志超,宋婷,薛祖光.Using CETSA assay and a mathematical mode lto reveal dual Bcl-2/Mcl-1 inhibition and on-target mechanism for ABT-199 and S1[J],European Journal of Pharmaceutical Sciences,2019,142(15)
Patents
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Published Books
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Research Projects
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- 亚型特异性Hsp70抑制剂的设计合成、和抗肿瘤分子标志物研究,国家自然科学基金项目,2020-09-27,在研
- Bcl-2抑制剂类靶向抗癌药的创制,地市厅局（含县）项目,2019-01-01,2022-12-28,结题
- Study on the mechanism of bcl-2 family protein in Bcr/Abl non-dependent resistance of chronic myeloid leukemia,国家自然科学基金项目,2015-08-18,Continue
- De novo design of multiple-targeting drug molecules,国家自然科学基金项目,2012-09-25,2016-12-31,Continue
- Multi target antitumor compounds based on Bcl-2 family protein interaction network,国家自然科学基金项目,2014-08-17,Continue
- Evaluation of the activity of new compounds for tumor marker Bcl protein,企事业单位委托科技项目,2014-10-27,Complete