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Novel and efficient one-pot synthesis of N '-alkyl-N,N-dimethylacetamidines

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Indexed by:期刊论文

Date of Publication:2011-02-01

Journal:JOURNAL OF CHEMICAL RESEARCH

Included Journals:SCIE

Issue:2

Page Number:119-120

ISSN No.:1747-5198

Key Words:N'-alkyl-N,N-dimethylacetamidine; N,N-dimethylacetamide; primary amines; lithium chloride; methanol

Abstract:An efficient method for the synthesis of N'-alkyl-N,N-dimethylacetamidine derivatives under mild conditions and in excellent yields involved reacting primary alkylannines with N,N-dimethylacetamide in the presence of LiCl as a catalyst and methanol as the acetalising reagent.

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