Release Time:2019-03-09  Hits:

Indexed by: Journal Article

Date of Publication: 2009-08-01

Journal: JOURNAL OF CHEMICAL RESEARCH-S

Included Journals: SCIE

Issue: 8

Page Number: 508-510

ISSN: 0308-2342

Key Words: 2,2,3,3-tetramethylpropanecarboxylic acid; N,N-dimethylacetamide; reduction reaction; TiCl(4)/NaBH(4)

Abstract: An efficient one-pot procedure for the synthesis of amide derivatives of 2,2,3,3-tetramethylpropanecarboxylic acid (TMCA) that involves the treating of TMCA in N,N-dimethylacetamide (DMAC) with thionyl chloride and stoichiometric amounts of reactant amines has been developed. The combined reagent TiCl(4)/NaBH(4) was found to be effective for the reduction of the amide derivatives of TMCA to the corresponding amines.