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Indexed by:期刊论文

Date of Publication:2018-02-25

Journal:Chemical communications (Cambridge, England)

Included Journals:SCIE

Volume:54

Issue:16

Page Number:2028-2031

ISSN No.:1364-548X

Abstract:A catalytic asymmetric Michael addition/annulation process between pyrazolones and enynones towards enantioenriched pyranopyrazoles was developed. Key features include the development of a cinchona alkaloid with C6' steric bulk as a competent catalyst and the observation of a unique stereospecific deuteration alpha to the keto group via a conducted tour pathway.