期刊论文

Zhao, Liyuan

Lu, AH (reprint author), Dalian Univ Technol, Sch Chem Engn, State Key Lab Fine Chem, Dalian 716024, Peoples R China.; Wang, BM (reprint author), Dalian Univ Technol, Sch Pharmaceut Sci & Technol, State Key Lab Fine Chem, Dalian 716024, Peoples R China.

Bao, Xiaoze,Hu, Qingtao,Wang, Baomin,Lu, An-Hui

2018-03-21

CHEMCATCHEM

SCIE、EI

J

10

6

1248-1252

1867-3880

asymmetric catalysis; heterocycles; heterogeneous catalysis; nanostructures; supported catalysts

Porous carbon nanosheets (PCNs) were used for the first time as a support to immobilize a quinine-squaramide catalyst for the asymmetric Friedel-Crafts addition of pyrazolones to isatin ketimines. Relying on its open structure with a macroporous network as well as hydrophobicity, the PCN-supported catalyst presented catalytic performance comparable to its homogeneous catalyst; the products were obtained in high yields (up to 90%) with high ee values (up to 99%). Recycling batch reactions together with a continuous flow process confirmed the stability of the catalyst.