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Indexed by:期刊论文
Date of Publication:2017-04-07
Journal:ORGANIC LETTERS
Included Journals:SCIE、PubMed
Volume:19
Issue:7
Page Number:1862-1865
ISSN No.:1523-7060
Abstract:A general and practical organocatalytic asymmetric 1,3-dipolar cycloaddition of 3-amino oxindole-based azomethine ylides and alpha,beta-enones has been developed. This reaction delivered spiro[pyrrolidine-2,3'-oxindole] products in high yields with excellent regio- and enantioselectivities (up to 99% yield, >20:1 rr, 99% ee). In addition, an array of spiro[dihydropyrrole-2,3'-oxindoles] were readily accessed by oxidative dehydrogenation. Notably, the inversion of the diastereoselectivity of the spiro[pyrrolidine-oxindole] product could be easily achieved through a facile oxidation-reduction process.
Pre One:Assembly of Indolenines, 3-Amino Oxindoles, and Aldehydes into Indolenine-Substituted Spiro[pyrrolidin-2,3 '-oxindoles] via 1,3-Dipolar Cycloaddition with Divergent Diastereoselectivities
Next One:Synthesis, structural characterization and conversion of dinuclear iron-sulfur clusters containing the disulfide ligand: [Cp*Fe(mu-eta(2):eta(2)-bdt)(cis-mu-eta(1):eta(1)-S-2)FeCp*], [Cp*Fe(mu-S(C6H4S2))(cis-mu-eta(1):eta(1)-S-2)FeCp*], and [{
