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发布时间：2019-03-12

论文类型：期刊论文

发表时间：2018-09-01

发表刊物：MEASUREMENT

收录刊物：SCIE

卷号：125

页面范围：371-376

ISSN号：0263-2241

关键字：Portablemicroscope; FOA; preAL-FOA; postAL-FOA; High-resolution

摘要：A portable high-resolution microscope based on combination of fiber-optic array (FOA) and pre-amplification lens, which can overcome the magnification limit of FOA, was developed. By employing the amplification lens at the small-end of the FOA, the resolution was improved from 4.4 mu m to 1.0 mu m over a field of view (FOV) of 140 mu m x 100 mu m without using any algorithm processing, and the distortion only slightly increases from 0.13% to 0.19%. The distortion is still lower than that of normal lens-based microscopy. Moreover, the combination methods of the amplification lens and FOA were investigated, which including only FOA, the pre-amplification lens at the small-end of the FOA (termed preAL-FOA) and the post-amplification lens at the big-end of FOA (termed postAL-FOA). The result proved the best resolution was achieved by using the preAL-FOA This microscopy is suitable for real-time monitoring of cells in microfluidic systems.