宋波

个人信息Personal Information

副教授

博士生导师

硕士生导师

性别:男

毕业院校:大连化物所

学位:博士

所在单位:化学学院

学科:分析化学

办公地点:大连理工大学西部校区化工综合楼D313

联系方式:+86-411-84986042

电子邮箱:bo.song@dlut.edu.cn

扫描关注

论文成果

当前位置: 中文主页 >> 科学研究 >> 论文成果

Syntheses of new chlorin derivatives containing maleimide functional group and their photodynamic activity evaluation

点击次数:

论文类型:期刊论文

发表时间:2015-10-01

发表刊物:BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

收录刊物:SCIE、PubMed、Scopus

卷号:25

期号:19

页面范围:4078-4081

ISSN号:0960-894X

关键字:Chlorin derivatives; Chlorin e6; Photo cytotoxic activity; Singlet oxygen

摘要:Nine new chlorin derivatives containing maleimide functional group and amino acid residue with chlorin e6 scaffold (compounds 1-6) or pheophorbide a scaffold (compounds 7-9) were synthesised from chlorophyll a. The all nine derivatives demonstrated increased photo cytotoxic activity in HepG2 cell (IC50 3.2-20.5 mu M) comparing with chlorin e6 and its trimethyl ester. Their photo cytotoxicities were approximately dependent on their abilities to produce singlet oxygen (O-1(2)) in the cells. (C) 2015 Published by Elsevier Ltd.