个人信息Personal Information
副教授
博士生导师
硕士生导师
性别:男
毕业院校:大连化物所
学位:博士
所在单位:化学学院
学科:分析化学
办公地点:大连理工大学西部校区化工综合楼D313
联系方式:+86-411-84986042
电子邮箱:bo.song@dlut.edu.cn
Syntheses of new chlorin derivatives containing maleimide functional group and their photodynamic activity evaluation
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论文类型:期刊论文
发表时间:2015-10-01
发表刊物:BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
收录刊物:SCIE、PubMed、Scopus
卷号:25
期号:19
页面范围:4078-4081
ISSN号:0960-894X
关键字:Chlorin derivatives; Chlorin e6; Photo cytotoxic activity; Singlet oxygen
摘要:Nine new chlorin derivatives containing maleimide functional group and amino acid residue with chlorin e6 scaffold (compounds 1-6) or pheophorbide a scaffold (compounds 7-9) were synthesised from chlorophyll a. The all nine derivatives demonstrated increased photo cytotoxic activity in HepG2 cell (IC50 3.2-20.5 mu M) comparing with chlorin e6 and its trimethyl ester. Their photo cytotoxicities were approximately dependent on their abilities to produce singlet oxygen (O-1(2)) in the cells. (C) 2015 Published by Elsevier Ltd.