Release Time:2019-03-12  Hits:

Indexed by: Journal Article

Date of Publication: 2016-10-12

Journal: ACS APPLIED MATERIALS & INTERFACES

Included Journals: Scopus、PubMed、EI、SCIE

Volume: 8

Issue: 40

Page Number: 26570-26577

ISSN: 1944-8244

Key Words: platelet-repellent surfaces; polyphenols; micropattern; platelet adhesion detection; antiplatelet drug

Abstract: Surface patterning provides a powerful tool to the diagnosis of platelet adhesion. However, the current methodologies of constructing platelet-patterned surfaces require laborious and complicated steps. Herein, a novel and simple platelet-repellent surface was reported by metal (Fe3+ ions)-polyphenol (tannic acid, TA) coordination interaction. The platelet repellent effect was significantly better than that of poly(ethylene glycol) (PEG) in a long-term. Moreover, the platelet-repellent behavior could extend to other polyphenols-functionalized surfaces. On the basis of these observations, a TA-based micropattern was fabricated in situ by one-step microcontact printing for well-defined platelet adhesion, which can effectively avoid the traditional introduction of inert hydrophilic polymers and bioactive ligands. Afterward, the TA-based micropattern was applied to monitor the adhesion of defective platelets treated with an antiplatelet drug (tirofiban). This work provided a facile, versatile, and environmentally friendly strategy to construct platelet-repellent polyphenolic surfaces and their micropattern. We expect that this simple micropattern could act as a low-cost and label-free platform for biomaterials and biosensors, and could be widely used in the clinical diagnoses of platelet adhesive functions and-the evaluation of antiplatelet therapies.