Release Time:2019-03-09  Hits:

Indexed by: Journal Papers

Date of Publication: 2015-10-01

Journal: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Included Journals: Scopus、PubMed、SCIE

Volume: 25

Issue: 19

Page Number: 4078-4081

ISSN: 0960-894X

Key Words: Chlorin derivatives; Chlorin e6; Photo cytotoxic activity; Singlet oxygen

Abstract: Nine new chlorin derivatives containing maleimide functional group and amino acid residue with chlorin e6 scaffold (compounds 1-6) or pheophorbide a scaffold (compounds 7-9) were synthesised from chlorophyll a. The all nine derivatives demonstrated increased photo cytotoxic activity in HepG2 cell (IC50 3.2-20.5 mu M) comparing with chlorin e6 and its trimethyl ester. Their photo cytotoxicities were approximately dependent on their abilities to produce singlet oxygen (O-1(2)) in the cells. (C) 2015 Published by Elsevier Ltd.