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论文类型：期刊论文

发表时间：2018-03-01

发表刊物：AICHE JOURNAL

收录刊物：SCIE、EI

卷号：64

期号：3

页面范围：835-859

ISSN号：0001-1541

关键字：chemotherapeutic drug; targeted drug delivery; fluorescence tracing; inorganic nanocarriers; fluorescence imaging

摘要：In recent years, anticancer nanomedicines have mainly been developed for chemotherapy and combination therapy in which the main contributing anticancer drugs are delivered by deliberately designed nano drug delivery systems (nano-DDSs). Inorganic nanocarriers equipped with fluorescent tracers have become attractive tools to monitor the whole drug delivery and release processes. The fluorescence signal of tracers could be observed concomitantly with drug release, and thus, this strategy is of great benefit to evaluate the therapeutic effects of the nano-DDSs. This review provides a brief overview about three inorganic nanocarriers for drug delivery, including mesoporous silica, Fe3O4, and hydroxyapatite. We mainly discussed about their preparation processes, drug loading capacities, and the development of different fluorescent materials (fluorescent dyes, quantum dots, fluorescent macromolecules, and rare earth metals) hybridized to nanocarriers for real-time monitoring of drug release both in vitro and in vivo. This review also provides some recommendations for more in-depth research in future. (C) 2017 American Institute of Chemical Engineers