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论文类型：期刊论文

发表时间：2018-06-18

发表刊物：CHEMISTRY-AN ASIAN JOURNAL

收录刊物：PubMed、SCIE

卷号：13

期号：12

页面范围：1625-1631

ISSN号：1861-4728

关键字：biocompatibility; fluorescent organic nanoparticles; hydrophilicity; multicolor cellular bioimaging

摘要：We demonstrated an unconventional polymerization route to synthesize hydrophilic fluorescent organic nanoparticles (FONs) for multicolor cellular bioimaging in this contribution. The route benefits from our unexpected discovery of a rapid polymerization reaction between 1,6-hexanediol dipropiolate and 2,4,6-triazide-1,3,5-triazine under the catalysis of N,N,N,N,N-pentamethyldiethylenetriamine (PMDETA). Interestingly, the 2,4,6-triazide-1,3,5-triazine and PMDETA system can also induce rapid free radical polymerization at room temperature. The as-prepared FONs exhibited promising water solubility and stability with an average diameter of 20nm. The excitation wavelength-dependent fluorescent properties endow the FONs with blue, yellow, and red fluorescent emission under UV, blue, and green excitation, respectively. The cytotoxicity of FONs was investigated by using a Cell Counting Kit (CCK-8) assay, which indicated good biocompatiblity. More importantly, the cell uptake experiment verified the FONs were excellent fluorescent nanoprobes for multicolor cellular bioimaging. Therefore, this unconventional route provides a novel fabrication strategy of highly hydrophilic FONs for biomedical applications.