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个人信息Personal Information
研究员
博士生导师
硕士生导师
性别：男
毕业院校：德国马普高分子所
学位：博士
所在单位：化工学院
办公地点：大连理工大学西部校区E-226
联系方式：sunwen@dlut.edu.cn
电子邮箱：sunwen@dlut.edu.cn
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An estrogen receptor targeted ruthenium complex as a two-photon photodynamic therapy agent for breast cancer cells
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论文类型：期刊论文
发表时间：2018-06-28
发表刊物：CHEMICAL COMMUNICATIONS
收录刊物：SCIE
卷号：54
期号：51
页面范围：7038-7041
ISSN号：1359-7345
摘要：In this study, we reported a tamoxifen modified Ru(ii) polypyridyl complex (Ru-tmxf) as an estrogen receptor (ER) targeted photosensitizer. Ru-tmxf displays enhanced cellular uptake and PDT efficiency toward breast cancer cells with high ER expression due to the specific targeting of tamoxifen to ER and finally localizes in lysosomes. Moreover, Ru-tmxf can be activated by two-photon excitation, generating O-1(2) to damage lysosomes and result in cell death.