Associate Professor
Supervisor of Master's Candidates
Academic Titles: Associate Professor in Biochemistry & Molecular Biology
Other Post: Vice Director, Panjin Institute of Industrial Technology (PIIT) of DUT
Paper Publications
Hydrolysis of plasmid DNA and RNA by amino alkyl naphthalimide as metal-free artificial nuclease
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Indexed by:Journal Article
Date of Publication:2006-02-15
Journal:BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Included Journals:PubMed、SCIE
Volume:16
Issue:4
Page Number:803-806
ISSN:0960-894X
Key Words:DNA cleavage; hydrolysis; naphthalimide; intercalator; selectivity; RNA
Abstract:A strategy of dimethylamino alkyldiimide conjugated with an intercalator of naphthalimide for hydrolysis of DNA was suggested and evaluated. 4 can hydrolyze 4 kb plasmid DNA into 2 kb fragments with GC and GG selectivity, which represents a novel example of sequence- or site-selective metal-free DNA artificial nuclease. Results also show it could hydrolyze RNA efficiently. (c) 2005 Elsevier Ltd. All rights reserved.
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