Jianqiang Xu   

Associate Professor
Supervisor of Master's Candidates

Main positions: Associate Professor in Biochemistry & Molecular Biology
Other Post: Vice Director, Panjin Institute of Industrial Technology (PIIT) of DUT

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Language:English

Paper Publications

Title of Paper:高度保守Trp114残基在TrxR1酶催化、寡聚化和氧化应激中的作用机制

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Date of Publication:2015-08-01

Page Number:121-121

Key Words:硒蛋白 硫氧还蛋白还原酶 硒代半胱氨酸 寡聚化 氧化应激 细胞死亡

Abstract:哺乳动物硒蛋白硫氧还蛋白还原酶(TrxR1)在维持细胞氧化还原平衡中发挥着关键作用。我们研究发现TrxR1 存在表位暴露的Trp114 残基,在进化上高度保守,但性质非常活泼、易于氧化,能够调控氧化还原过程。实验结果显示,Trp114 残基与酶的FAD 基团发生交互作用,是生理活性反应的电子中继站;Trp114 氧化引发该酶的寡聚化,从活性二聚体形成四聚体及高聚体。

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