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论文类型： 期刊论文

发表时间： 2017-10-01

发表刊物： APPLIED MATHEMATICS AND MECHANICS-ENGLISH EDITION

收录刊物： Scopus、SCIE、EI

卷号： 38

期号： 10

页面范围： 1481-1496

ISSN号： 0253-4827

关键字： shallow Y-shaped microfluidic channel; dynamic biochemical signal; non-reversing pulsatile flow; nonlinear amplitude-frequency modulation; Taylor-Aris dispersion

摘要： The transports of the dynamic biochemical signals in the non-reversing pulsatile flows in the mixing microchannel of a Y-shaped microfluidic device are ana- lyzed. The results show that the mixing micro-channel acts as a low-pass filter, and the biochemical signals are nonlinearly modulated by the pulsatile flows, which depend on the biochemical signal frequency, the flow signal frequency, and the biochemical signal transporting distance. It is concluded that, the transfer characteristics of the dynamic biochemical signals, which are transported in the time-varying flows, should be carefully considered for better loading biochemical signals on the cells cultured on the bottom of the microfluidic channel.