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发表时间： 2022-10-09

发表刊物： 水动力学研究与进展A辑

期号： 6

页面范围： 679-684

ISSN号： 1000-4874

摘要： Intracellular calcium signals in vascular endothelial cells are closely related to the regulation of cell function. Fluid shear stress and ATP are two important regulators of intracellular calcium signals. Based on the dynamic mathematical model of intracellular calcium signals induced by shear stress and ATP, a quantitative regulation of calcium signaling in vascular endothelial cells by controlling shear stress and ATP is presented by using the PID feedback controller and the method of numerical simulation. The results show that the intracellular calcium signals in vascular endothelial cells could be quantitatively well controlled by controlling shear stress and ATP signals with appropriate controller parameters for three different types of reference intracellular calcium signals, including sinusoidal wave, square wave, and "LN", which is the acronym of "LiaoNing"; More accurate and quantitative control of intracellular calcium signals in vascular endothelial cells could be implemented by controlling shear stress signals than ATP signals. The results in this paper also provide a certain theoretical feasibility and methodology base for further in-depth study of the quantitative relationships among shear stress, ATP, calcium signals and endothelial cellular function. ? 2015, Publishing House for Journal of Hydrodynamics. All right reserved.

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