李昂，男，助理教授。本科毕业于上海交通大学，博士毕业于美国明尼苏达大学，读博研究期间在David D. Thomas实验室通过时间分辨荧光能量共振转移(TR-FRET)技术，从分子能量水平研究SERCA2a/DWORF/PLB之间相互作用以及RyR2功能水平对心肌细胞钙信号转导的影响，取得了一系列成果。博士后阶段合作导师上海生化所李林院士课题组多年来研究Wnt信号转导的蛋白质相互作用网络及其调控的分子机制，实验室的研究工作围绕Wnt信号转导通路展开，包括Wnt信号膜质传递、细胞核内转录复合物调控、β-catenin入核机制等方面，已经取得突破性的进展。

教育经历：

2015.9-2021.12 University of Minnesota（明尼苏达大学）

生物化学、分子生物学与生物物理系 | 博士

导师：David D. Thomas

2010.9-2014.6 上海交通大学

生物科学 | 本科

导师：吴更

论文成果：

(1) Ang Li*, Yuanyuan Shen, Zhenyan Li and Lin Li*. Wnt/β-catenin pathway induces cardiac dysfunction via AKAP6-mediated RyR2 phosphorylation and sarcoplasmic reticulum calcium leakage. Journal of Molecular Cell Biology. 2025.

(2) Samantha L.Yuen, Ang Li, Evan W. Kleinboehl, Lauren N. Roelike, Andrew R. Thompson, Philip A. Bidwell, Razvan L. Cornea and David D. Thomas*. Fluorescence lifetime FRET assay for live-cell high-throughput screening of the cardiac SERCA pump yields multiple classes of small-molecule allosteric.  Journal of Biological Chemistry. 2023.

(3) Ang Li, SL Yuen, DR Stroik, E Kleinboehl, RL Cornea, and DD Thomas*. The transmembrane peptide DWORF activates SERCA2a via dual mechanisms.  Journal of Biological Chemistry. 2021.

(4) Ang Li, Daniel Stroik, Tory Schaaf, Samantha Yuen, Evan Kleinboehl, Razvan L.Cornea, David D.Thomas*. Biophysics of the SERCA2A/DWORF Complex, Implications for Treatment of Heart Failure. Biophysical Journal. 2020.

(5) TM Schaaf, Ang Li, BD Grant, K Peterson, S Yuen, P Bawaskar, E Kleinboehl, J Li, DD Thomas*, and GD Gillispie. Red-shifted FRET biosensors for high-throughput fluorescence lifetime screening. Biosensors. 2018.

(6) Ma Rui, Ang Li, Wang Yujiong, Zhang Yong*. Co-expression and Purification of Recombinant Ego1 in Complex with Ego3 from Saccharomyces cerevisiae. Chinese Journal of Cell Biology. 2014.

(7) Ang Li, Yong Zhang, Che Wang, Geng Wu*, Zhenchun Wang. Purification, molecular cloning, and antimicrobial activity of peptides from the skin secretion of the black-spotted frog, Rana nigromaculata. World Journal of Microbiological Biotechnology. 2013.

主持/参与科研项目：

2020.1-至今

自然科学基金委 (NSFC), 重大研究计划：92053201，Wnt信号调控DNA损伤修复的机制研究及靶向干预。

2020.3-2023.3

National Institutes of Health (NIH), RO1HL139065-37, Structural Dynamics of Cardiac Muscle Calcium 

ATPase Regulation.

2017.3-2020.3

National Institutes of Health (NIH), RO1HL139065-36, Structural Dynamics of Cardiac Muscle Calcium 

ATPase Regulation.