点击次数：

发布时间：2019-09-16

论文类型：期刊论文

发表时间：2018-01-01

发表刊物：MACROHETEROCYCLES

收录刊物：SCIE

卷号：11

期号：4

页面范围：378-382

ISSN号：1998-9539

关键字：Photodynamic therapy; chlorin e(6); artesunate; reactive oxygen species; pholoexcitation

摘要：In the development of new photosensitizers jar cancer therapy, increasing the capacity of intracellular reactive oxygen species (ROS) production is an important strategy. In this paper, artesunate as a ROS generation group was regioselectively introduced to the chlorin e(6) scaffold to obtain four conjugates of chlorin e(6) and artesunate. By irradiation with 440 nm, 630 nm and 660 nm of light source the four conjugates exhibited significantly improved phototoxicity against HepG2 cells compared with chlorin e(6) and artesunate. Irradiation with 440 nm or 660 nm light source gave higher phototoxicity as well as intracellular ROS level.