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论文类型： 期刊论文

发表时间： 2016-12-01

发表刊物： PHYTOCHEMISTRY LETTERS

收录刊物： SCIE、Scopus

卷号： 18

页面范围： 157-161

ISSN号： 1874-3900

关键字： Talaromyces wortmannii; Polyketides; OSMAC; Absolute configuration; Anthelmintic activity; NADH-fumarate reductase inhibitor

摘要： Three new polyketides, wortmannilactones I1-I3, were purified from Talaromyces wortmannii using the One Strain Many Compounds (OSMAC) strategy. The polyketides' structures were established using IR, 1D and 2D NMR, and HRESIMS analyses and the absolute configurations were identified by comparison of experimental and calculated ECDs. These polyketides exhibit selective inhibitory activity against NADH-fumarate reductase. (C) 2016 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.