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论文类型： 期刊论文

发表时间： 2016-11-01

发表刊物： BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

收录刊物： SCIE、PubMed、Scopus

卷号： 26

期号： 21

页面范围： 5328-5333

ISSN号： 0960-894X

关键字： Wortmannilactones; Talaromyces wortmannii; Epigenome manipulation; Suberoylanilide hydroxamic acid; NADH-fumarate reductase

摘要： With the aim of finding more potential inhibitors against NADH-fumarate reductase (specific target for treating helminthiasis and cancer) from natural resources, Talaromyces wortmannii was treated with the epigenome regulatory agent suberoylanilide hydroxamic acid, which resulted in the isolation of four new wortmannilactones derivatives (wortmannilactones 1-L, 1-4). The structures of these new compounds were elucidated based on IR, HRESIMS and NMR spectroscopic data analyses. These four new compounds showed potent inhibitory activity against NADH-fumarate reductase with the IC50 values ranging from 0.84 to 1.35 mu M. (C) 2016 Elsevier Ltd. All rights reserved.