PERSONAL INFORMATION Surname: Qu Given name: Mingbo Date of Birth: January, 1984 Place of Birth: Liaoning Province, China Citizenship: China Sex: male Work phone: 086-411-8470-7245 Email: mingboqu@dlut.edu.cn Mail Address: School of Life science and Biotechnology, Dalian University of Technology, No.2 Linggong Road, High-Tech Zone District, Dalian City, Liaoning Province, P. R. China EDUCATION Sep. 2006 – Apr. 2012: Ph.D. (Biochemical Engineering) School of Environmental and Biological Science and Technology, Dalian University of Technology, Dalian, China. Sep. 2002 – July 2006: B.S. (Biotechnology) School of Environmental and Biological Science and Technology, Dalian University of Technology, Dalian, China. EXPERIENCE Dec. 2017 – present: Associate Professor, School of Environmental and Biological Science and Technology, Dalian University of Technology, Dalian, China. Jan. 2015 – Dec. 2017: Lector, School of Environmental and Biological Science and Technology, Dalian University of Technology, Dalian, China. June 2012 – Jan. 2015: Postdoctor, School of Environmental and Biological Science and Technology, Dalian University of Technology, Dalian, China. Oct. 2008 – Oct. 2009: Visiting scholar, Department of Molecular and Cell Biology, Berkeley, University of California, CA, USA. RESEARCH INTEREST Chitin is an important structure component during the development of insect. It protect insect from environmental damage and pathogen invasion. Our project is to identify crucial proteins that participate in the metabolism of chitin in insects and then study these proteins as potential pesticide targets. Our final goal is to design biopesticides according to these targets to control the pest and manipulate these proteins for other applications. Our research includes: 1. Identify important proteins related with chitin metabolism using transcriptome and proteome. 2. Uncover physiological significance of proteins related with chitin metabolism using molecular biology, biochemistry and structure biology methods. 3. Using RNAi based technique for biocontrol of insects RESEARCH GRANT SUPPORT 1. The National Natural Science Foundation of China, 2015-2017, No. 31402015, ￥240,000; 2. The National Key Research and Development Program of China, 2017-2020, No. 2017YFD0201207, ￥185,000; 3. The Fundamental Research Funds for the Central Universities, 2017-2018, No. DUT17RC(4)13, ￥50,000; 4. The China Postdoctoral Science Foundation funded project, 2017-2018, No. 2017M611234, ￥50,000. 5. The Fundamental Research Funds for the Central Universities, 2015-2016, No. DUT15RC(3)031, ￥50,000; 6. The China Postdoctoral Science Foundation funded project, 2017-2018, No. 2013M530122, ￥80,000. PUBLICATIONS 1. Chen,W., Qu, M. #, Zhou, Y., Yang Q.*, Structural analysis of group II chitinase (ChtII) catalysis completes the puzzle of chitin hydrolysis in insects. Journal of Biological Chemistry, doi: 10.1074/jbc.RA117.000119; 2. Liu, L., Qu, M.#, Yang, J., Yang Q.*, The physiological differentiation along the midgut of Bombyx mori --- inspirations from the proteomics and gene expression patterns of the secreted proteins in the ectoperitrophic space. Insect Molecular Biology, doi: 10.1111/imb.12368; 3. Qu, M., Ren, Y., Liu, Y., Yang, Q.*, Studies on the chitin/chitosan binding properties of six cuticular proteins analogous to peritrophin 3 from Bombyx mori. Insect Molecular Biology, 2017, 26: 432-439; 4. Qu, M., Ma, L. #, Chen, P., Yang, Q.*, Proteomic analysis of insect molting fluid with a focus on enzymes involved in chitin degradation, Journal of Proteome Research, 2014, 13: 2931-2940; 5. Qu, M., Liu, T., Chen, P., Yang, Q.*, A sperm–plasma β-N-Acetyl-D-Hexosaminidase interacting with a chitinolytic β-N-Acetyl-D-Hexosaminidase in insect molting fluid，PLoS ONE, 2013, 8(8): e71738; 6. Qu, M., Yang, Q.*, Physiological significance of alternatively-spliced exon combinations of the single-copy gene OfCHSA in the insect Ostrinia furnacalis (Lepidoptera), Insect Molecular Biology, 2012, 21(4): 395-404; 7. Qu, M., Yang, Q.*, A novel alternative splicing site of class A chitin synthase from the insect Ostrinia furnacalis --- gene organization, expression pattern and physiological significance, Insect Biochemistry and Molecular Biology, 2011, 41(12): 923-931; 8. Qu, M., Liu, T., Yang, J., Yang, Q., The gene, expression pattern and subcellular localization of chitin synthase B from the insect Ostrinia furnacalis, Biochemical and Biophysical Research Communications, 2011, 404(1): 302-307; 9. Chen, L., Zhou, Y., Qu, M., Zhao, Y., Yang, Q.*, Fully deacetylated chitooligosaccharides act as efficient glycoside hydrolase family18 chitinase inhibitors. Journal of Biological Chemistry, 2014. 289(25): 17932-17940; 10. Huo, Y., Chen, L., Qu, M., Chen, Q., Yang, Q.*, Biochemical characterization of a novel β-N-acetyl-D-hexosaminidase from the insect Ostrinia furnacalis, Archives of Insect Biochemistry and Physiology, 2013, 83(3): 115-126; 11. Liu, F., Liu, T., Qu, M., Yang, Q.*, Molecular and biochemical characterization of a novel β-N-acetyl-D-hexosaminidase with broad substrate-spectrum from the Asian corn borer, Ostrinia furnacalis, International Journal of Biological Sciences, 2012, 8(8): 1085-1096; 12. Yang, Q.*, Yan, J., Liu, T., Qu, M., Liu, F., Insect chitin-remodeling enzymes: Physiological roles, applications and preparation. In: Liong, M.T. (eds.), Bioprocess Sciences and Technology, Nova Science Publishers, Chapter XVI, 2011, 381-408. # co-author; * corresponding author LECTURES 1. July 2017, the 3rd International Conference of Insect Genomics & the 6th International Symposium on Insect Physiology, Biochemistry and Molecular Biology, Oral presentation: The physiological differentiation along the midgut of Bombyx mori; 2. Sep. 2016, the XXV International Congress of Entomology, Oral presentation: Recombinant expression, purification and chitin binding specificity of different CPAP3s from Bombyx mori; 3. June 2015, the 5th International Symposium on Insect Physiology, Biochemistry and Molecular Biology, Oral presentation: Proteomic analysis of insect molting fluid uncovered a "211" combination of chitinolytic enzymes involved in chitin degradation; 4. Oct. 2014, The 1st International Symposium on Insecticide Toxicology, Oral presentation: A sperm–plasma β-N-acetyl-D-hexosaminidase interacting with a chitinolytic β-N-acetyl-D-hexosaminidase in insect molting fluid; 5. July 2013, The 4th International Symposium on Insect Physiology, Biochemistry and Molecular Biology, Oral presentation: A novel alternative splicing of class A chitin synthases from the insect Ostrinia furnacalis; 6. May 2013, The 6th International Workshop on Insect Transgenesis, Oral presentation: Alternative splicing of class A chitin synthases from the insect Ostrinia furnacalis; 7. July 2011, The 3rd International Symposium on Insect Physiology, Biochemistry and Molecular Biology, Oral presentation: Chitin synthases in Ostrinia furnacalis.