在英国爱丁堡大学攻读博士学位，其间成功合成了具有保护及促进神经细胞生长显著生物活性的倍半萜类天然产物Merrilactone A 和Anislactone A&B，其中Anislactone A&B是国际首次全合成。2011年获得默克研究基金资助，在美国顶级生物医学化学研究所The Scripps Research Institute（斯克利普斯研究所）从事博士后研究，成功合成了Myceliothermophins、Otermycin和Dioporthichalasin等具有抗肿瘤活性的聚酮类天然产物，此研究可望为创新抗癌药物研发提供先导化合物，同时参与了广谱抗菌素CJ-16，264的国际首次全合成。
      长期致力于有机合成方法学和复杂天然产物的全合成研究，迄今为止在Angew. Chem. Int. Ed.、J. Am. Chem. Soc.、Chemistry - A European Journal等国际知名杂志上共发表学术论文十多篇。其中，1篇被Angew. Chem. Int. Ed.选为热点论文HOT PAPER，2 篇被Thieme旗下著名评论期刊Synfacts选为亮点重点推介，他引总数千于次。为Strategies and Tactics in Organic Synthesis丛书（Elsevier，2013）撰写章节一篇，其研究工作多次被化学领域顶级杂志期刊引用并专题评述，研究成果得到了相关领域学术界的关注并产生了一定的影响力。

 

目前研究工作集中于：

1）过渡金属与可见光协同催化的新型反应

2）低碳烯烃等工业原料向精细化学品的转化

Publications:

#43 Metal and Photocatalyst-Free Amide Synthesis via Decarbonylative Condensation of Alkynes and Photoexcited Nitroarenes

Organic Letter, 2024, 26, 39, 8222-8227  

https://pubs.acs.org/doi/10.1021/acs.orglett.4c02513

Rongqi Cui, Qian Liao, Yuanxia Zhao, Lifang Wang, Yongqiang Zhang, Shuyang Liu, Ziyu Gan, Yufei Chen, Yi Shi, Lei Shi, Min Li, Yunhe Jin*

#42 Photoinduced Phosphoniumation of Aryl Halides and Arylthianthrenium Salts via an Electron Donor–Acceptor Complex 

Organic Letter, 2024, 26, 36, 7751-7756

https://pubs.acs.org/doi/10.1021/acs.orglett.4c02909

Ziyu Gan, Jiajin Chen, Han Wang, Zhiyan Xue, Ziyang Chen, Yongqiang Zhang, Lifang Wang, Hui Zi, Shuyang Liu, Lei Shi, Yunhe Jin*

#41 Iron-Catalyzed Photoredox a-C-H Alkylation and Tandem Intramolecular Cyclization: Facile Access to Multisubstituted 2,3-Dihydrofutans and y-Butyrolactones 

Organic Letter, 2024, 26, 25, 5329-5334  

https://pubs.acs.org/doi/full/10.1021/acs.orglett.4c01719

Jiajin Chen, Ziyu Gan, Yongqiang Zhang, Ziyang Chen, Shuyang Liu, Rongqi Cui, Zhiyan Xue, Haoxiang Sun, Lei Shi, Wen-Feng Jiang, and Yunhe Jin*

#40 Radical allylation of aldehydes with allenes by photoredox cobalt and chromium dual catalysis

Synthesis, 2024, 56,  

https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-1774866

Haoyu Li, Xin Wang, Renxu Cao, Xuehan Qi, Erjun Hao, Lei Shi*

s-0043-1774866.pdf

#39 Chemoselective Functionalization of Tertiary C-H Bonds of Allylic Ethers: Enantioconvergent Access to sec,tert-Vicinal Diols

Angewandte Chemie International Edition, 2024,  in revision 

http://xxx

#38 Selective Hydroaminoalkylation of 1,3-Dienes by Dual Photoredox and Nickle Catalysis

Organic Letter, 2024, in revision

https://pubs.acs.org/doi/

#37 Titanium Catalyzed [2σ+2π] Cycloaddition of bicyclo[1.1.0]-butanes with 1,3-dienes for efficient synthesis of stilbene bioisosteres   

Nature Communications, 2024, 15, 4374

https://www.nature.com/articles/s41467-024-48494-9 2024-Nature_Communications.pdf

Yonghong Liu,  Zhixian Wu, JingRan Shan, Huaipu Yan, Erjun Hao, Lei Shi*

#36 Photochemical Metal-Hydride Hydrogen Atom Transfer Mediated Radical Functionalization of Dienes and Allenes

ChemCatChem, 2024, 16, e202301344

http://dx.doi.org/10.1002/cctc.202301344.

ChemCatChem - 2023 - Yan - Photochemical Metal‐Hydride Hydrogen Atom Transfer Mediated Radical Hydrofunctionalization of.pdf

Huaipu Yan,  Jingran Shan, Lei Shi*

#35 Photoredox Chromium and Cobalt Dual Catalysis Enabled Carbonyl Allylation with Dienes via Hydrogen Atom Transfer

From the themed collection: 2023 Organic Chemistry Frontiers HOT articles

Organic Chemistry Fronties, 2024,11, 684-689 

https://pubs.rsc.org/en/content/articlelanding/2024/qo/d3qo01403g

ocf 1 d3qo01403g.pdf

Huaipu Yan, Dandan Zhang, Yonghong Liu, Xin Wang, Zhixian Wu, Yunhe Jin, Xiaobo Ding, Jingran Shan, Erjun Hao, Lei Shi*

#34 Photoexcited Hantzsch esters Enabled [2π+2σ] Cycloadditions of Bi-cyclo [1.1.0] butanes and Alkenes

Organic Letter, 2023, 25, 45, 8116-8120 

https://pubs.acs.org/doi/10.1021/acs.orglett.3c03222

Huaipu Yan, Yonghong Liu, Xiao Feng, Lei Shi*

Dear Prof. Shi,  

Congratulations on having one of the most viewed articles in OL in November for “Hantzsch Esters Enabled [2π+2σ] Cycloadditions of Bicyclo [1.1.0] butanes and Alkenes under Photo Conditions"!  We look forward to receiving your top-notch manuscripts for OL in the future.  

Sincerely,  

Marisa Kozlowski, Ph.D. 

Editor-in-Chief Organic Letters

#33 Radical crotylation of aldehydes with 1,3-butadiene by photoredox cobalt and titanium dual catalysis

Organic Letter, 2023, 25, 42, 7694-7699  

https://pubs.acs.org/doi/10.1021/acs.orglett.3c03003 

Huai pu, Yan, Jingran Shan, Fengzhi Zhang, Yuqing Chen, Xinyi Zhang, Qian Liao, Hao, Erjun, Shi, Lei,*   

#32 Recent Progress on [3+2] Ring-Expansion Reaction of Aziridines with Unsaturated Compounds

Chinese Journal of Organic Chemistry, 2023 

http://sioc-journal.cn/Jwk_yjhx/CN/10.6023/cjoc202305008

Hao, Erjun,* Ding, Xiaobo, Wang, Kexin, Zhou, Honghao, Yang, Qiliang, Shi, Lei,*   

#31 Photoinduced copper-catalyzed selective three-component 1,2-amino oxygenation of 1,3-dienes

Chemical Communication, 2023, 59, 10388-1031 

https://pubs.rsc.org/en/Content/ArticleLanding/2023/CC/D3CC02769D

Yonghong Liu, Huaipu Yan, Yuqing Chen, Erjun Hao, and Lei Shi*

#30 Difunctionalization of 1,3-Butadiene via Sequential Radical Thiol-ene Reaction and Allylation by Dual Photoredox and Titanium Catalysis

Organic Letter, 2023, 23, 25, 5094-5099

https://pubs.acs.org/doi/full/10.1021/acs.orglett.3c01822  orglett.pdf

Erjun Hao*, Binghui Lu, Yonghong Liu, Tianxiao Yang, Huaipu Yan, Xiaobo Ding, Yunhe Jin, and Lei Shi*

#29 Photocatalytic Metal Hydride Hydrogen Atom Transfer Mediated Allene Functionalization by Cobalt and Titanium Dual Catalysis

Angewandte Chemie International Edition, 2023,  DOI：10.1002/anie.202302483 

https://onlinelibrary.wiley.com/doi/10.1002/anie.202302483  Angew Chem Int Ed - 2023 - Yan.pdf

Huaipu Yan, Qian Liao, Yuqing Chen, Gagik G. Gurzadyan, Binghui Lu, Chao Wu, and Lei Shi*

#28 Visible-Light-Induced Radical Cascade Cross-Coupling via C(sp3)–H Activation and C–N/N–O Cleavage: Feasible Access to Methylenebisamide Derivatives

Organic Letter, 2023, 25, 13, 2300-2305

https://pubs.acs.org/doi/10.1021/acs.orglett.3c00646

Jinglan Lei, Min Li, Qingqing Zhang, Shuyang Liu, Haifang Li, Lei Shi, Wen-Feng Jiang, Chunying Duan, and Yunhe Jin*

#27 Redox-Neutral Synthesis of π-Allylcobalt Complexes from Alkenes for Aldehyde Allylation via Photoredox Catalysis

Green Chemistry, 2022, 24, 9027-9032

https://pubs.rsc.org/en/content/articlelanding/2022/gc/d2gc02990a d2gc02990a.pdf

Dandan Zhang, Haoyu Li, Zhuowen Guo, Yuqing Chen, Huaipu Yan, Zenghui Ye, Fengzhi Zhang, Binghui Lu, Erjun Hao, and Lei Shi*

#26 Photochemical Nozaki–Hiyama–Kishi Coupling Enabled by Excited Hantzsch Ester

Organic Letter, 2022, 24, 18, 3331-3336 Selected as Cover art

https://pubs.acs.org/doi/10.1021/acs.orglett.2c00877文章点击下载.pdf

Yonghong Liu, Shuangjie Lin, Dandan Zhang, Bingkun Song, Yunhe Jin, Erjun Hao, and Lei Shi*

#25 Synthesis of Homoallylic Amines by Radical Allylation of Imines with Butadiene under Photoredox Catalysis

Angewandte Chemie International Edition, 2022, 61, 29, e202204516

https://onlinelibrary.wiley.com/doi/10.1002/anie.202204516 文章点击下载.pdf

Yuqing Chen,Huaipu Yan,Qian Liao,Dandan Zhang,Shuangjie Lin,Erjun Hao,Rukhsana Murtaza,Chenchen Li,Chao Wu,Chunying Duan,Lei Shi*

#24 Wearable healthcare smart electrochemical biosensors based on co-assembled prussian blue—graphene film for glucose sensing

Microchimica Acta, 2022, 189, 46

https://link.springer.com/article/10.1007/s00604-021-05087-3   Health.pdf

Junlin Ma, Yuhang Du, Yu Jiang, Liuxue Shen, Hongting Ma, Fengjuan Lv, Zewei Cui, Yuzhen Pan, Lei Shi, Nan Zhu*

#23 A base-free Chan–Lam reaction catalyzed by an easily assembled Cu(II)-carboxylate metal-organic framework

Journal of Chemical Research, 2021, 45, 7-8, 795-799

https://journals.sagepub.com/doi/10.1177/17475198211026506   chanlam.pdf

Xinhai Zhang, Jianhua Qin, Ruixuan Ma, and Lei Shi

#22 Activation of Chromium Catalysts by Photoexcited Hantzsch Ester for Decarboxylative Allylation of Aldehydes with Butadiene

Organic Letter, 2021, 23, 20, 8077-8081

https://pubs.acs.org/doi/10.1021/acs.orglett.1c03098文章点击下载.pdf

Shuangjie Lin, Yuqing Chen, Huaipu Yan, Yonghong Liu, Yuchen Sun, Erjun Hao, Caizhe Shi, Dandan Zhang, Nan Zhu, Lei Shi*

#21 Photocatalytic Generation of π-allyltitanium Complexes from Butadiene via a Radical Strategy

Synthesis, 2021, 53, 1889-1900 invited Feature Article by Professor Paul Knochel 

https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0040-1706024 s-0040-1706024.pdf

Fusheng Li,^‡ Shuangjie Lin,^‡ Xiyu Li,  Lei Shi*

 

#20 Photocatalytic Umpolung Synthesis of π-allylcobalt Complexes for Allylation of Aldehydes

ACS Catalysis, 2021, 11, 2992-2998

https://pubs.acs.org/doi/10.1021/acscatal.0c05330acscatal.0c05330.pdf

Caizhe Shi,^‡ Fusheng Li,^‡ Yuqing Chen, Shuangjie Lin, Erjun Hao, Zhuowen Guo, Urwa Tul Wosqa, Dandan Zhang, Lei Shi*

#19 Photocatalytic Generation of π-allyltitanium Complexes via Radical intermediates

Angewandte Chemie International Edition, 2021, 60, (3), 1561-1566 

https://doi.org/10.1002/anie.202010780  文章点击下载.pdf

Fusheng Li, Shuangjie Lin, Yuqing Chen, Caizhe Shi, Huaipu Yan,  ChenChen Li, Chao Wu, Luqing Lin, Chunying Duan, and Lei Shi*

#18 Cp₂Ti^IIICl catalysis in a new light 

ChemPhotoChem, 2020, 4, 659-663, invited article

https://doi.org/10.1002/cptc.20200008516820023.pdfreprint (3).pdf

Yuqing Chen, Shuangjie Lin,  Fusheng Li,  Xinhai Zhang,  Luqing Lin,  Lei Shi*

#17 Visible-light-mediated Barbier allylation of aldehydes and ketones via dual titanium and photoredox catalysis

Org. Chem. Front., 2020, 7, 3434-3438

https://doi.org/10.1039/D0QO00171Fd0qo00171f.pdf

Fu-sheng Li,‡ Yu-qing Chen,‡ Shuang-jie Lin, Cai-zhe Shi, Xi-yu Li, Yu-chen Sun, Zhuo-wen Guo, and Lei Shi*

#16 

Visible-light-driven spirocyclization of epoxides via dual titanocene and photoredox catalysis 

Chem. Sci., 2020, 11, 839-844 Advance Article

https://doi.org/10.1039/C9SC05601Gc9sc05601.pdf

Shuangjie Lin, Yuqing Chen, Fusheng Li, Caizhe Shi, Lei Shi*

#15 

“In situ immobilization” of a multicomponent chiral catalyst (MCC) via non-covalent interactions for heterogeneous asymmetric hydrogenation reactions

Org. Chem. Front., 2020, 7, 345-349 c9qo01331h.pdf

https://doi.org/10.1039/C9QO01331H

Er-Jun Hao, Gong-Xin Li, Zhen-Zhen Lv, Fu-Sheng Li, Yu-Qing Chen, Shuang-Jie Lin, Cai-Zhe Shi and Lei Shi*

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   所获奖励：

1. Overseas Research Students Awards Scheme (ORSAS), UK, 2007-2010
2. Engineering and Physical Sciences Research’s fellowship, UK, 2007-2010
3. Merck Research Fellowship Awards, US, 2011-2012

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   代表性论文：

   1. K. C. Nicolaou,* Akshay A. Shah, Henry Korman, Tabrez Khan, Lei Shi,Wisuttaya Worawalai,and Emmanuel A. Theodorakis Total Synthesis and Structural Revision of Antibiotic CJ-16,264. Angewandte Chemie, International Edition. 2015. 54，9203-9208

Antibiotic CJ‐16.pdf

   2. Nicolaou, K. C.*; Lei Shi, Min Lu, Manas R. Pattanayak, Heraklidia A. Ioannidou,Manjunath Lamani, Total synthesis of Myceliothermophins C and D. Angewandte Chemie, International Edition. 2014. 49，10970-10974 

Myceliothermophins.pdf

   3. Nicolaou, K. C.*; Yu, Ruocheng; Shi, Lei; Cai, Quan; Lu, Min; Heretsch, Philipp, A General Synthetic Approach to Functionalized Dihydrooxepines, Organic Letters, 2013, 15(8), 1994-1997.
   4. Micheal Greaney*, Lei Shi, Naim, Total synthesis of (±) Anislactone A and (±) Merrilactone A, Strategies and Tactics in Organic Synthesis, 2013, Vol 9, 105-147.
   5. Xuefeng Jiang, Lei Shi, Hui Liu, Akbar H. Khan and Jason S. Chen, Gas extrusion in natural products total synthesis. Org. Biomol. Chem., 2012, 10, 8383-8392 (review).
   6. Lei Shi, Karsten Meyer and Michael F. Greaney*, Synthesis of (±) Merrilactone A and (±) Anislactone A. Angewandte Chemie, International Edition. 2010, 49, 9250-9253.

Merrilactone A.pdf

   7. Lei Shi, Xingwang Wang, Christian A. Sandoval, Zheng Wang, and Kuiling Ding*, Development of Continuous Flow System for Asymmetric Hydrogenation Using Self-Supported Chiral Catalysts, Chemistry - A European Journal. 2009,15, 9855-9867 (full paper).
   8. DING Kuiling*, Wang Zheng, SHI Lei, Self-Supported Chiral Catalysts for Heterogeneous Enantioselective Reactions. Pure Applied Chemistry, 2007, 79, 1531-1540 (review).
   9. Lei shi, Xingwang Wang, Mingxing Li, Zhanting Li, Kuiling Ding*, Engineering polymeric chiral catalyst using hydrogen bonding and metal-to-ligand coordination interaction, Angewandte Chemie, International Edition. 2006, 45, 4108-4112.
   10. Xingwang Wang, Lei Shi, Mingxing Li, Kuiling Ding*, Heterogenization of Shibasaki's Binol/La Catalyst for Enantioselective Epoxidation of α,β-Unsaturated Ketones with Multitopic Binol Ligands: The Impact of Bridging Spacers, Angewandte Chemie, International Edition 2005, 44, 6362-6366.
   11. Yuxue Liang, Qing Jing, Xin Li, Lei Shi, Kuiling Ding*, Programmed Assembly of Two Different Ligands with Metallic Ions: Generation of Self-Supported Noyori- type Catalysts for Heterogeneous Asymmetric Hydrogenation of Ketones, Journal of the American Chemical Society 2005, 127, 7694-7695.
   12. Shi Lei, Wang Zheng, Wang Xingwang, Li Mingxing; Ding Kuiling*, A new method for chiral catalyst immobilization: Self-supporting strategy Chinese Journal of Organic Chemistry, 2006, 26, 1444-1456 (review).
   13. LI Ming-Xing*, DAI Hui, SHAO Min, SHI Lei, LIN Kun-Hua, CHENG Zhi-Xuan, WENG Lin-Hong，Synthesis, Crystal Structures, Thermal Analysis and Magnetic Property of Mono- and Binuclear 1,1-Cyclobutanedicarbox-late Copper Complexes, Chinese Journal of Chemistry. 2006, 487.

   14. Boyan Yu, Erjun Hao, Shaoming Fang, Zhengqing Liu, Yongwei Wang, Zhenzhen Lv, Na Li,  Xinyu Zhang, Lei Shi* and Yaping Du*，Controlled synthesis of high quality scandium-based nanocrystals as promising recyclable catalysts for silylcyanation reaction，Nanoscale, 2017,9, 10987-10991

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   招生信息：

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