Indexed by:期刊论文
Date of Publication:2018-01-01
Journal:Materials science & engineering. C, Materials for biological applications
Included Journals:PubMed、SCIE、EI
Volume:87
Page Number:90-103
ISSN No.:1873-0191
Key Words:Micro-arc oxidation; Micro/nano dual-scale structure; TiO2 coating; Crocompatibility; Osseointegration
Abstract:A novel "cortex-like" micro/nano dual-scale structured TiO2 coating was prepared on a titanium surface by micro-arc oxidation (MAO) with tetraborate electrolytes. This structure, which combines microslots with nanopores, exhibits super hydrophilicity. This coating modified the surface structure, chemistry, and hydrophilicity in a one-step treatment. Evolution of the coating together with its surface and structure properties was studied. We propose a forming mechanism of the dual-scale structure in which the oxides formed during the MAO discharge dissolve in the tetraborate electrolytes, leaving little or no deposition outside the discharge channels. We performed in vitro tests using human bone marrow-derived mesenchymal stem cells (hBMSCs) that compared this coating with a "volcano-like" MAO coating and a commercial sandblasted, large-grit and acid-etched (SLA) coating. The adhesion, morphology, proliferation, and differentiation of hBMSCs, together with the matrix mineralization, were investigated. Results suggest that the "cortex-like" structure significantly promotes the adhesion, spreading, and differentiation of cells and increases the matrix mineralization. In vivo tests with mongrel dogs showed an excellent osseointegration of the "cortex-like" coating. The combination of the dual-scale structure and the hydrophilicity of the "cortex-like" TiO2 coating synergistically resulted in an outstanding cytocompatibility and osseointegration, which may facilitate a higher level of implant success. Copyright © 2018 Elsevier B.V. All rights reserved.
Associate Professor
Supervisor of Doctorate Candidates
Supervisor of Master's Candidates
Gender:Male
Alma Mater:Dalian University of Technology
Degree:Doctoral Degree
School/Department:School of Materials Science & Engineering
Discipline:Materials Science. Biomedical Engineering
Business Address:Room 224
School of Materials Science and Engineering,
Dalian University of Technology,
Liaoning 116024,
P. R. of China
Contact Information:15641198386
腾讯QQ : 558132
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