Indexed by:期刊论文
Date of Publication:2008-11-01
Journal:MEDICAL ENGINEERING & PHYSICS
Included Journals:SCIE、EI、PubMed、Scopus
Volume:30
Issue:9
Page Number:1177-1185
ISSN No.:1350-4533
Key Words:Topology optimization; Drug-eluting stents; Finite element methods; In-stent restenosis; Biomechanical properties
Abstract:The new generation of drug-eluting stents (DES) is required to control drug release kinetics. A novel DES (the Conor stent) with drug reservoirs on struts has been engineered. Topology optimization of one Conor stent strut was based on the commercial finite element analysis code OptiStruct, with the aim of increasing the strut stiffness while retaining its drug holding capacity. Results show that the element density distribution of the strut model was optimized with manufacturing constraints of extrusion constraint and minimum member size control. The optimal result was directly transformed to a clear, manufacturable design concept using the OptiStruct utility OSSmooth. The final manufacturing design increased the strut stiffness and yielded better stress distribution, as compared to the original strut design under the same loading. Topology optimization may help designers devise novel stent platforms for future DES with drug reservoirs and adequate scaffolding (C) 2008 IPEM. Published by Elsevier Ltd. All rights reserved.
Associate Professor
Supervisor of Doctorate Candidates
Supervisor of Master's Candidates
Gender:Male
Alma Mater:Dalian University of Technology
Degree:Doctoral Degree
School/Department:School of Materials Science & Engineering
Discipline:Materials Science. Biomedical Engineering
Business Address:Room 224
School of Materials Science and Engineering,
Dalian University of Technology,
Liaoning 116024,
P. R. of China
Contact Information:15641198386
腾讯QQ : 558132
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