Indexed by:期刊论文
Date of Publication:2016-09-02
Journal:粘接
Included Journals:ISTIC
Issue:9
Page Number:20-28
ISSN No.:1001-5922
Key Words:SIS-g-NPEO共聚物;热熔压敏胶;体外药物释放;经皮给药系统
Abstract:通过原位环氧化反应与开环接枝反应相结合,将亲水性壬基酚聚氧乙烯醚(NPE0)支链引入聚苯乙烯-异戊二烯-苯乙烯(SIS)三嵌段共聚物,制备功能型SIS-g-NPEO热塑弹性体,并以SIS-g-NPEO为骨架,配以增粘树脂、矿物油、氢化松香树脂、抗氧剂等组分,制备了面向经皮给药系统的SIS-g-NPE0热熔压敏胶,以栀子苷为亲水性模型药物,研究SIS-g-NPE0热熔压敏胶中各组分对栀子苷的释放影响.结果显示,C5树脂和增塑剂PEG有利于栀子苷释放;矿物油不利于亲水性成分栀子苷的释放.
Associate Professor
Supervisor of Doctorate Candidates
Supervisor of Master's Candidates
Gender:Male
Alma Mater:Dalian University of Technology
Degree:Doctoral Degree
School/Department:Dept. of Polymer Materials
Discipline:Polymer Materials. Polymer Chemistry and Physics. Chemistry and Chemical Engineering of Functional
Business Address:Chemical Experiment Building A303, West Campus
Contact Information:Tel：+86-411-84986101
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