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个人信息Personal Information
教授
博士生导师
硕士生导师
主要任职：计算机科学与技术学院院长
其他任职：计算机学院院长
性别：男
毕业院校：西安电子科技大学
学位：博士
所在单位：计算机科学与技术学院
学科：计算机应用技术
联系方式：E-Mail: zhangq@dlut.edu.cn
电子邮箱：zhangq@dlut.edu.cn
Programmable Regulation of DNA Conjugation to Gold Nanoparticles via Strand Displacement
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论文类型：期刊论文
发表时间：2017-10-31
发表刊物：LANGMUIR
收录刊物：SCIE、EI、PubMed、Scopus
卷号：33
期号：43
页面范围：12285-12290
ISSN号：0743-7463
摘要：Methods for conjugating DNA to gold nanoparticles (AuNPs) have recently attracted considerable attention. The ability to control such conjugation in a programmable way is of great interest. Here, we have developed a logic-based method for manipulating the conjugation of thiolated DNA species to AuNPs via cascading DNA strand displacement. Using this method, several logic-based operation systems are established and up to three kinds of DNA signals are introduced at the same time. In addition, a more sensitive catalytic logic-based operation is also achieved based on an entropy-driven process. In the experiment, all of the DNA/AuNPs conjugation results are verified by agrose gel. This strategy promises great potential for automatically conjugating DNA stands onto label-free gold nanoparticles and can be extended to constructing DNA/nanoparticle devices for applications in diagnostics, biosensing, and molecular robotics.