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个人信息Personal Information
教授
博士生导师
硕士生导师
主要任职：计算机科学与技术学院院长
其他任职：计算机学院院长
性别：男
毕业院校：西安电子科技大学
学位：博士
所在单位：计算机科学与技术学院
学科：计算机应用技术
联系方式：E-Mail: zhangq@dlut.edu.cn
电子邮箱：zhangq@dlut.edu.cn
Nicking enzyme-controlled toehold regulation for DNA logic circuits
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论文类型：期刊论文
发表时间：2017-12-14
发表刊物：NANOSCALE
收录刊物：SCIE、EI
卷号：9
期号：46
页面范围：18223-18228
ISSN号：2040-3364
摘要：DNA strand displacement is widely used in DNA-related nanoengineering for its remarkable specificity and predictability. We report a nicking enzyme-assisted mechanism to regulate strand displacement, where DNA toeholds are dynamically controlled. To demonstrate the strategy, a protein/DNA-based Boolean operation system is constructed and based on it a two-channel multiplexer controlled by three different nicking enzymes is realized. The proposed regulatory mechanism can be used for switch logic statement and bridges protein and DNA logic circuits.