赵剑楠 博士

化学学院 特聘研究员

赵剑楠博士毕业于四川大学，师从冯小明院士，博士研究方向为烯酮亚胺参与的不对称Mannich反应。2015年加入加州大学洛杉矶分校(UCLA) Ohyun Kwon教授课题组开展博士后研究工作，首次实现了可见光催化的交叉[2+2]环加成反应。2018年10月，入职大连理工大学。主要研究兴趣为新型自由基反应开发，光催化连续流反应设计，及手性药物和具有生物活性化合物的合成研究。目前为止，已取得了多项创新性研究成果，在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Org. Lett., Org. Chem. Front.等刊物发表多篇SCI论文。应邀参加于德国林岛举办的第65届诺贝尔奖获得者大会，并获得后续资助。

诚招博后、研究助理、博士、硕士研究生以及交流生

Publications：

[18]  Chuyu Xiao,^# Jing-Ran Shan,^# Wen-Deng Liu, Xingyuan Gao, Jingwei Dai, Zuwei Wang, Wentao Wang, K. N. Houk,* Jiannan Zhao* "Stereoselective Radical Acylfluoroalkylation of Bicyclobutanes via N-Heterocyclic Carbene Catalysis" Angew. Chem. Int. Ed., 2024, accepted, DOI:10.1002/anie.202416781.

[17]  Wen-Deng Liu, Jiyuan Gao, Jia-Nan Mo, Yuqiao Zhou,* Jiannan Zhao* "Cooperative NHC and Photoredox Catalyzed Radical Aminoacylation of Alkenes to Tetrahydropyridazines" Chem. Eur. J. 2024, 30, e202402288. (Invited Paper)

        Published as part of Special Collection "Chirality: From Small Molecules to Macromolecules"

[16]  Jia-Nan Mo, Shengbin Sun, Huiwei Xu, Hanyu Shu, Jiannan Zhao* "Synthesis of γ‑Oxo-phosphonates via N‑Heterocyclic CarbeneCatalyzed Acylphosphorylation of Alkenes" Org. Lett. 2024, 26, 2197−2201.

        Published as part of Virtual Special Issue "Radical Reactions for the Construction and Transformation of Complex Molecules"

[15]  Hanyu Shu^#, Jia-Nan Mo^#, Wen-Deng Liu, Jiannan Zhao* "Synthesis of Pyrroloindolines via N‑Heterocyclic Carbene Catalyzed Dearomative Amidoacylation of Indole Derivatives"  Org. Lett. 2023, 25, 8677−5584.

[14]  Junqi Su, Aobo Chen, Guofeng Zhang, Ziyu Jiang, Jiannan Zhao* "Photocatalytic Phosphine-Mediated Thioesterification of Carboxylic Acids with Disulfides" Org. Lett. 2023, 25, 8033−8037.

[13]  Junqi Su, Jia-Nan Mo, Guofeng Zhang, Ziyu Jiang, Jiannan Zhao* "A Practical Approach for Oligopeptide Synthesis via Synergistic Photoredox, Cobaloxime and Organophosphorus Triple Catalysis" Org. Chem. Front. 2023, 10, 4895−4904.

        Highlighted by Synfacts 2024, 20, 105.

[12]  Huiwei Xu, Wanyao Zheng, Wen-Deng Liu, Yuqiao Zhou,* Luqing Lin, Jiannan Zhao* "Silylacylation of Alkenes through N‑Heterocyclic Carbene Catalysis" Org. Lett. 2023, 25, 5579−5584.

[11]   Wencheng Han, Wen-Deng Liu, Junqi Su, Jiannan Zhao* "Deoxygenation of Oximes for the Synthesis of Pyrrolines via Hydroimination Cyclization" Org. Biomol. Chem. 2023, 21, 3350−3354.

[10]  Huiwei Xu, Jia-Nan Mo, Wen-Deng Liu, Jiannan Zhao* "N-Heterocyclic Carbene-Catalyzed Remote C(sp³)–H Acylation of Amides" Tetrahedron Lett. 2023, 121, 154483.

[9]  Wen-Deng Liu^#, Woojin Lee^#, Hanyu Shu, Chuyu Xiao, Huiwei Xu, Xiangyang Chen, Kendall N. Houk*, Jiannan Zhao* "Diastereoselective Radical Aminoacylation of Olefins through N-Heterocyclic Carbene Catalysis" J. Am. Chem. Soc. 2022, 144, 22767−22777. 

       Highlighted by Synfacts 2023, 19, 183.

 

[8]  Wencheng Han, Junqi Su, Jia-Nan Mo, Jiannan Zhao* "Photoredox Catalytic Phosphine-Mediated Deoxygenation of Hydroxylamines Enables the Construction of N-Acyliminophosphoranes" Org. Lett. 2022, 24, 6247−6251.

 

[7]   Jiannan Zhao Introducing... Angew. Chem. Int. Ed. 2022, 61, e202116270.

[6] Junqi Su, Jia-Nan Mo, Xiangyang Chen, Alexander Umanzor, Zheng Zhang, Kendall N. Houk, Jiannan Zhao* “Generation of Oxyphosphonium Ions by Photoredox/Cobaloxime Catalysis for Scalable Amide and Peptide Synthesis in Batch and Continuous-Flow” Angew. Chem. Int. Ed., 2022, 61, e202112668. (Hot Paper, Cover)

[5]   Jia-Nan Mo, Junqi Su, Jiannan Zhao* "The Asymmetric A³(Aldehyde–Alkyne–Amine) Coupling: Highly Enantioselective Access to Propargylamines" Molecules 2019, 24, 1216.

[4]    Jiannan Zhao, Jonathan L. Brosmer, Qingxuan Tang, Zhongyue Yang, K. N. Houk, Paula L. Diaconescu, Ohyun Kwon*“Intramolecular Crossed [2+2] Photocycloaddition through Visible Light-Induced Energy Transfer”J. Am. Chem. Soc. 2017, 139, 9807−9810.

[3]    Jiannan Zhao, Bing Fang, Weiwei Luo, Xiaoyu Hao, Xiaohua Liu, Lili Lin, and Xiaoming Feng* “Enantioselective Construction of Vicinal Tetrasubstituted Stereocenters by the Mannich Reaction of Silyl Ketene Imines with Isatin-Derived Ketimines”Angew. Chem. Int. Ed., 2015, 54, 241–244.

[2]    Jiannan Zhao, Xiaohua Liu, Weiwei Luo, Mingsheng Xie, Lili Lin, and Xiaoming Feng* “Asymmetric Synthesis of β-Amino Nitriles through a Sc^III-Catalyzed Three-Component Mannich Reaction of Silyl Ketene Imines”Angew. Chem. Int. Ed., 2013, 52, 3473–3477.

[1]   Jiannan Zhao, Ke Zheng, Yang Yang, Jian Shi, Lili Lin, Xiaohua Liu, Xiaoming Feng*“Asymmetric Mukaiyama Aldol Reaction Catalyzed by C₂-Symmetric N,N'-Dioxide–Ni(II) Complex”Synlett, 2011, 903–906. 

Book Chapters:

Jiannan Zhao, Shunxi Dong, Xiaoming Feng*, "[4+2]-Cycloadditions (Inverse-Electron-Demand Hetero-Diels-Alder Reaction)" Elsevier, DOI:10.1016/B978-0-32-390644-9.00002-0.