周宇涵

个人信息Personal Information

教授

博士生导师

硕士生导师

任职 : 药学系副主任

性别:男

毕业院校:大连理工大学

学位:博士

所在单位:化工学院

学科:药物工程. 药物化学. 精细化工

办公地点:大连理工大学西校区化工实验楼G415

联系方式:0411-84986192

电子邮箱:zhouyh@dlut.edu.cn

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发表论文与专著

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 近年来,主要论文如下:

 

[1]      Nan Cai, Xiang Gao, Wenjin Li, Li Yang, Jinfeng Zhao, Jingping Qu, Yuhan Zhou.* Novel trifluoromethyl ketone derivatives as oral cPLA2/COX-2 dual inhibitors for resolution of inflammation in rheumatoid arthritis. Bioorg. Chem. 2024, 148, 107453(1-20).

[2]      Nan Cai, Xiang Gao, Li Yang, Wuding Sun, Shuaibo Zhang, Jinfeng Zhao, Jingping Qu, Yuhan Zhou.* Discovery of novel NSAID hybrids as cPLA2/COX-2 dual inhibitors alleviating rheumatoid arthritis via inhibiting p38 MAPK pathway. Eur. J. Med. Chem. 2024, 267, 116176(1-21).

[3]      Shuaibo Zhang, Dong Li, Bangzhong Wang, Wuding Sun, Haojun Ma, Kai Di, Luyang Sun, Jinfeng Zhao, Jingping Qu, Yuhan Zhou.* Palladium-catalyzed asymmetric trifluoromethylated allylic alkylation of N-substituted glycine ethyl esters with α-(trifluoromethyl)alkenyl acetates. Eur. J. Org. Chem. 2023, 26, e202300593 (1-5).

[4]      Xuejian Li, Bangzhong Wang, Dong Li, Jinfeng Zhao, Jingping Qu, Yuhan Zhou.* KI-Mediated chlorine gas-free synthesis of 3,3-dichloro-2-oxindole derivatives. Eur. J. Org. Chem. 2023, 26, e202201452 (1-7).

[5]      Dong Li, Shuaibo Zhang, Bangzhong Wang,Wuding Sun, Jinfeng Zhao, Jingping Qu, Yuhan Zhou.* Palladium-catalyzed stereoselective trifluoromethylated allylic alkylation of 3-substituted oxindoles. Org. Chem. Front. 2022, 9(3), 810-815. (微信公众号Frontiers Journals专题报道:https://mp.weixin.qq.com/s/QRYSrYy8FzMAgbbnN2c7mg).

[6]      Dong Li, Wande Zhang, Shuaibo Zhang, Wuding Sun, Jinfeng Zhao, Baomin Wang, Jingping Qu, Yuhan Zhou.* Palladium-catalyzed asymmetric trifluoromethylated allylic alkylation of pyrazolones enabled by α-(trifluoromethyl)alkenyl acetates. Org. Lett. 2021, 23(15), 5804-5808.

[7]      Chunxia Zhang, Dong Li, Yilong Zhao, Jinfeng Zhao, Jingping Qu, Yuhan Zhou.* Base-free Suzuki–Miyaura coupling of (Z)-trifluoromethyl alkenyl triflates: an efficient approach to α-trifluoromethyl arylenes. ChemistrySelect 2020, 5, 13099-13102.

[8]      Junyan Zhao, Xun Song, Dong Li, Jinfeng Zhao, Jingping Qu, Yuhan Zhou.* Intramolecular dehydrogenative coupling approach to 2-oxindoles using Fe(OAc)2/NaI/Na2S2O8. Eur. J. Org. Chem. 2020, 6392-6398.

[9]      Dong Li, Shujun Lv, Jingping Qu, Yuhan Zhou.* Oxidation of 4-aryl-1,1,1-trifluorobut-2-en-2-yl trifluoromethanesulfonates by 4-picoline-N-oxide: a novel approach to β-trifluoromethyl-α,β-enones. Synthesis 2020, 52, 1203-1210.

[10]   Yu Cao, Wuding Sun, Gen Luo, Yang Yu, Yuhan Zhou, Yanan Zhao, Jimin Yang, Y Luo. Mechanistic Insights into La-Catalyzed Amidation of Aldehyde with Amine. Org. Lett. 2020, 22(2), 705-708.

[11]   Yang Liu, Yuhan Zhou,* Dong Li, Han Chen, Jinfeng Zhao, Jingping Qu. Iron-catalyzed boration of cinnamyl carbonates: a highly stereoselective approach to cyclopropylboronates. Org. Chem. Front. 2019, 6, 983-988.

[12]   Han Chen, Sijia Sun, Haoying Xi, Kaifang Hu, Ning Zhang, Jingping Qu, Yuhan Zhou.* Catalytic oxidative conversion of aldehydes into nitriles using NH3•H2O/FeCl2/NaI/Na2S2O8: a practical approach to febuxostat. Tetrahedron Lett. 2019, 60, 1434-1436.

[13]   Yuhan Zhou, Chunxia Zhang, Yilong Zhao, Dong Li, Jinfeng Zhao, Zhaotian Wang, Jingping Qu. Base-promoted double-bond-migration/hydrolysis/isomerization of 4-aryl-1,1,1-trifluorobut-2-en-2-yl trifluoromethanesulfonates: a metal-free approach to β-trifluoromethyl ketones. Eur. J. Org. Chem. 2018, 6217-6222.

[14]   Dong Li, Yuhan Zhou*, Yilong Zhao, Chunxia Zhang, Jianzhe Li, Jinfeng Zhao, Jingping Qu. Synthesis of 2-trifluoromethyl-2-hydroxy-2H-chromenes via cyclization of (Z)-trifluoromethyl alkenyl triflates and salicylaldehydes. J. Fluorine Chem. 2018, 212, 122-129.

[15]   Yilong Zhao, Yuhan Zhou,* Chunxia Zhang, Dong Li, Puhua Sun, Jianzhe Li, Huan Wang, Jianhui Liu, Jingping Qu. Base-controlled regiodivergent azidation of trifluoromethyl alkenyl triflates: transition-metal-free access to CF3-containing allyl azides and alkenyl azides. J. Org. Chem. 2018, 83(5), 2858-2868.

[16]   Yuhan Zhou,* Huan Wang, Yang Liu, Yilong Zhao, Chunxia Zhang, Jingping Qu. Iron-catalyzed boration of allylic alcohols with H3BO3 as an additive. Synth. Commun. 2018, 48(7), 795-801.

[17]   Yang Liu, Yuhan Zhou,* Yilong Zhao, Jingping Qu. Synthesis of gem-difluoroallylboronates via FeCl2-catalyzed boration/β-fluorine elimination of trifluoromethyl alkenes. Org. Lett. 2017, 19(4), 946-949.

[18]   Yuhan Zhou,* Huan Wang, Yang Liu, Yilong Zhao, Chunxia Zhang and Jingping Qu. Iron-catalyzed boration of allylic esters: an efficient approach to allylic boronates. Org. Chem. Front. 2017, 4(8), 1580 - 1585.

[19]   Yilong Zhao, Yuhan Zhou,* Chunxia Zhang, Huan Wang, Jinfeng Zhao, Kun Jin, Jihong Liu, Jianhui Liu, Jingping Qu. Palladium-catalyzed geometrically selective hydrogenation of (Z)-trifluoromethyl alkenyl triflate: an efficient approach to (Z) or (E)-3,3,3-trifluoropropenyl derivatives. Org. Biomol. Chem. 2017, 15(27), 5693-5700. (Inside front cover, 2017 Hot Articles).

[20]   Yuhan Zhou,* Ling Li, Xiaoliang Dong, Yixin Zhang, Dawei Yang, Yang Liu, Jingping Qu.* Synthesis of diiron sulfur clusters containing thiolato-1,8-naphthalene imide ligand. Inorg. Chem. Commun. 2017, 80, 10-14.

[21]   Yuhan Zhou,* Changpeng Wu, Xiaoliang Dong, Jingping Qu. Synthesis of 6-trichloromethylphenanthridines by transition metal-free radical cyclization of 2-isocyanobiphenyls. J. Org. Chem. 2016, 81(12), 5202-5208.

[22]   Yilong Zhao, Yuhan Zhou,* Juan Liu, Dongmei Yang, Liang Tao, Yang Liu, Xiaoliang Dong, Jianhui Liu, Jingping Qu. Synthesis of (Z)-α-trifluoromethyl alkenyl triflate: a scaffold for diverse trifluoromethylated species. J. Org. Chem. 2016, 81(11), 4797-4806.

[23]   Yuhan Zhou,* Xiaoliang Dong, Yixin Zhang, Peng Tong, and Jingping Qu*. Highly selective fluorescence sensors for the fluoride anion based on carboxylate-bridged diiron complexes. Dalton Trans. 2016, 45, 6839-6846. (back cover)

[24]   Changpeng Wu, Yuhan Zhou,* Xiaoliang Dong, Jingping Qu. Synthesis of 6-(arylthio)phenanthridines by cyclization reaction of 2-isocyanobiphenyls with thiols. ARKIVOC 2016, (iii), 110-124.

[25]   Yang Liu, Yuhan Zhou,* Huan Wang and Jingping Qu. FeCl2-catalyzed hydroboration of aryl alkenes with bis(pinacolato)diboron. RSC Adv. 2015, 5, 73705-73713.

[26]   Xiaoliang Dong, Litao Liu, Yuhan Zhou,* Jun Liu, Yixin Zhang, Yanhui Chen, and Jingping Qu.* Synthesis of carboxylate-bridged iron-thiolate clusters from alcohols/aldehydes or carboxylate salts. Dalton Trans. 2015, 44, 14952-14958.

[27]   Xiaoliang Dong, Yuhan Zhou,* Yuming Song, Jingping Qu. Anthracene-Fe3+ ensemble based turn-on fluorescent probes for selective detection of fluoride. J. Fluorine Chem. 2015, 178, 61-67.

[28]   Dongmei Yang, Yuhan Zhou,* Yuming Song, Jingping Qu. A practical synthesis of trifluoromethyl alkyl ketones. J. Fluorine Chem. 2015, 173, 6-11.

[29]   Yuhan Zhou,* Yuming Song, Yang Liu, Jingping Qu. A convenient one-pot preparation of spiro[fluorene-9,9’-xanthene]-3’,6’-diol derivatives. ARKIVOC 2015 (v), 99-109.

[30]   Weiguo Song, Liangjun Dong, Yuhan Zhou,* Yongqiang Fu, Wenfang Xu. Catalytic asymmetric synthesis of esomeprazole by a titanium complex with a hexaaza triphenolic macrocycle ligand. Synth. Commun., 2015, 45(1), 70-77.

[31]   Yuhan Zhou,* Dongmei Yang, Gen Luo, Yilong Zhao, Yi Luo,* Na Xue, Jingping Qu. Highly selective trifluoroacetic ester/ketone metathesis: an efficient approach to trifluoromethyl ketones and esters. Tetrahedron 2014, 70(31), 4668-4674.

[32]   Yuhan Zhou,* Guchao Gao, Yuming Song, Jingping Qu*. Enantioselective reduction of prochiral ketones with NaBH4/Me2SO4/(S)-Me-CBS. Synth. Commun., 2014, 44(10), 1515-1520.

[33]   杨冬梅,周宇涵,* 常晴,赵一龙,曲景平. 三氟甲基烷基酮的生物活性及合成方法. 化学进展 2014, 26(6), 976-986.

[34]   Xiaoneng Cui, Jianzhang Zhao, Yuhan Zhou, Jie Ma, Yilong Zhao. Reversible photoswitching of triplet-triplet annihilation upconversion using dithienylethene photochromic switches. J. Am. Chem. Soc. 2014, 136, 9256-9259.

[35]   Dongmei Yang, Yuhan Zhou,* Na Xue, Jingping Qu.* Synthesis of trifluoromethyl ketones via tandem claisen condensation and retro-claisen CC bond-cleavage reaction. J. Org. Chem. 2013, 78(8), 4171-4176. (“organic-chemistry.org”专题报道: J42-Y2013)

[36]   Jinfeng Zhao, Lei Wang, Yuhan Zhou,* Yixin Zhang, Nan Zhang, Chunmei Jia, Fengshuo Hu, Yanhui Chen, Baomin Wang, Jingping Qu.* Synthesis, structure and reactions of triply selenolate-bridged diiron complex [Cp*Fe(µ-SeMe)3FeCp*]. Inorg. Chem. Commun. 2013, 29, 179-182.

[37]   Weiguo Song, Yuhan Zhou,* Yongqiang Fu, Wenfang Xu. Self-disproportionation of enantiomers of prazoles via achiral, gravity-driven silica gel column chromatography. Tetrahedron: Asymmetry 2013, 24(15-16), 909-912.

[38]   Yang Li, Ying Li, Baomin Wang, Yi Luo, Dawei Yang, Peng Tong, Jinfeng Zhao, Lun Luo, Yuhan Zhou, Si Chen, Fang Cheng, Jingping Qu. Ammonia formation by a thiolate-bridged diiron amide complex as a nitrogenase mimic. Nature Chem. 2013, 5(4), 320-326.

[39]   Jinfeng Zhao, Lei Wang, Yuhan Zhou, Yixin Zhang, Nan Zhang, Yanhui Chen, Jingping Qu. Synthesis and characterization of a thiolate-bridged diiron complex with two monocoordinated azido ligands: [Cp*Fe(μ-SMe)N3]2 (Cp* = η5-C5Me5). Chinese J. Struc. Chem. 2013, 32 (7), 1083-1087.

[40]   Guowei Wang, Baomin Wang, Shuai Qi, Jinfeng Zhao, Yuhan Zhou, Jingping Qu*. Highly enantio- and diastereoselective vinylogous aldol reaction by LiCl-assisted BINOL―titanium speciesOrg. Lett. 2012, 14, 2734-2737.

[41]   董晓亮,周宇涵*,徐珊珊,曲景平*. 5-芳甲氧基苯基吡唑衍生物的合成及除草活性. 有机化学, 2011, 31(7), 1020-1026.

[42]   赵金凤,窦海建,周宇涵,曲景平. (S,S)-TsDPEN-Ru催化不对称氢转移还原β-胺基酮及在度洛西汀合成中的应用. 高等学校化学学报2011, 32 (10), 2331-2334.

[43]   Yuhan Zhou, Thomas Lecourt, Laurent Micouin. Direct synthesis of 1,4-disubstituted-5-alumino-1,2,3-triazoles by a copper-catalyzed cycloaddition of organic azides and mixed-aluminum acetylides. Angew. Chem. Int. Ed. 2010, 49(14), 2607-2610 (Synfacts 2010, 6, 0704).

[44]   Yuhan Zhou,* Na Xue, Guowei Wang, Jingping Qu. Synthesis, structure and herbicidal activity of substituted phenyl pyrazole derivatives. J. Chem. Res.2010, 34(12), 684-688.

[45]   Guowei Wang, Jinfeng Zhao, Yuhan Zhou, Baomin Wang, Jingping Qu. Mild and highly enantioselective vinylogous aldol reaction of brassard’s diene with aromatic aldehydes by combined Lewis acid catalyst. J. Org. Chem. 2010, 75(15), 5326-5329 Synfacts 2010, 6, 1266.

[46]   Yuhan Zhou,* Yanhui Chen, Weirong Miao, Jingping Qu. Synthesis, structures and herbicidal activity of isoxazole derivatives. J. Heterocyclic Chem. 2010, 47(6), 1310-1316.

[47]   Yinsong Tao, Yuhan Zhou, Jingping Qu, Masanobu Hidai. Highly efficient and regioselective allylic amination of allylic alcohols catalyzed by [Mo3PdS4] cluster. Tetrahedron Lett. 2010, 51, 1982-1984.

[48]   Na Xue, Yuhan Zhou,* Guowei Wang, Weirong Miao, Jingping Qu.* Syntheses and herbicidal activity of pyrazolyl benzoxazole derivatives. J. Heterocyclic Chem. 2010, 47(1): 15-21 (Top accessed papers from 2010).

[49]   Pingping Chen, Yanhui Chen, Yuhan Zhou, Ying Peng, Jingping Qu, Masanobu Hidai. Heterometallic cubane-type clusters [MMo3S4] (M = Au, Ag and Cu): synthesis, structures and electrochemical properties. Dalton Trans. 2010, 39, 5658 – 5663.

[50]   Yuhan Zhou, Thomas Lecourt, Laurent Micouin. Room temperature Lewis base-catalyzed alumination of terminal alkynes. Adv. Synth. Catal. 2009, 351(16): 2595-2598.

[51]   Yanhui Chen, Yuhan Zhou, Pingping Chen, Yinsong Tao, Yang Li, Jingping Qu. Nitrogenase model complexes [Cp*Fe(μ-SR1)2(μ-η2-R2N=NH)FeCp*] (R1 = Me, Et; R2 = Me, Ph; Cp* = η5-C5Me5): synthesis, structure, and catalytic N-N bond cleavage of hydrazines on diiron centers. J. Am. Chem. Soc. 2008, 130(46): 15250-15251 (JACS β Select issue 9).

[52]   Yuhan Zhou, Guchao Gao, Hui Li, Jingping Qu. A convenient method to reduce hydroxyl-substituted aromatic carboxylic acid with NaBH4/Me2SO4/B(OMe)3, Tetrahedron Lett. 2008, 49, 3260-3263.

[53]   Yanhui Chen, Yuhan Zhou, Jingping Qu. Synthesis and reactions of novel triply thiolate-bridged diiron complexes [Cp*Fe(µ2-SR)3FeCp*] (Cp*= η5-C5Me5; R = Et, Ph), Organometallics 2008, 27(4), 666–671.

  

  

专著


[1]      Yuhan Zhou*, Xiaoliang Dong, Jingping Qu. Synthesis, structure and herbicidal activity of pyrazole derivatives. in Daiki Kobayashi and Eito Watanabe Edit: Handbook on Herbicides: Biological Activity, Classification and Health & Environmental Implications (Chapter 13) USA: Nova Science Publishers, 2013, 263-276 (2013-12).

[2]      Serge Mignani, Yuhan Zhou, Thomas Lecourt, Laurent Micouin. Recent Developments in the Synthesis 1,4,5-Trisubstituted Triazoles. Topics in Heterocyclic Chemistry Vol. 28: Click Triazoles. (Edited by Janez Košmrlj.) Springer-Verlag Berlin Heidelberg: 2012, 185-232.

[3]      李和平,周宇涵,冯光柱,申艳敏,黄雪,刘云,袁超,何利霞. 含氟溴碘精细化学品. 北京:化学工业出版社,2010-09-01.(“十一五国家重点图书”)

[4]      李和平,冯光柱,魏文珑,孙建军,周宇涵,黄雪. 含氯精细化学品. 北京:化学工业出版社,2010-08-01. (“十一五国家重点图书”)