有机合成新方法研究

药物合成

不对称催化

化学制药工艺

 近年来，主要论文如下：

[1]      Nan Cai, Xiang Gao, Wenjin Li, Li Yang, Jinfeng Zhao, Jingping Qu, Yuhan Zhou.* Novel trifluoromethyl ketone derivatives as oral cPLA₂/COX-2 dual inhibitors for resolution of inflammation in rheumatoid arthritis. Bioorg. Chem. 2024, 148, 107453(1-20).

[2]      Nan Cai, Xiang Gao, Li Yang, Wuding Sun, Shuaibo Zhang, Jinfeng Zhao, Jingping Qu, Yuhan Zhou.* Discovery of novel NSAID hybrids as cPLA₂/COX-2 dual inhibitors alleviating rheumatoid arthritis via inhibiting p38 MAPK pathway. Eur. J. Med. Chem. 2024, 267, 116176(1-21).

[3]      Shuaibo Zhang, Dong Li, Bangzhong Wang, Wuding Sun, Haojun Ma, Kai Di, Luyang Sun, Jinfeng Zhao, Jingping Qu, Yuhan Zhou.* Palladium-catalyzed asymmetric trifluoromethylated allylic alkylation of N-substituted glycine ethyl esters with α-(trifluoromethyl)alkenyl acetates. Eur. J. Org. Chem. 2023, 26, e202300593 (1-5).

[4]      Xuejian Li, Bangzhong Wang, Dong Li, Jinfeng Zhao, Jingping Qu, Yuhan Zhou.* KI-Mediated chlorine gas-free synthesis of 3,3-dichloro-2-oxindole derivatives. Eur. J. Org. Chem. 2023, 26, e202201452 (1-7).

[5]      Dong Li, Shuaibo Zhang, Bangzhong Wang,Wuding Sun, Jinfeng Zhao, Jingping Qu, Yuhan Zhou.* Palladium-catalyzed stereoselective trifluoromethylated allylic alkylation of 3-substituted oxindoles. Org. Chem. Front. 2022, 9(3), 810-815. (微信公众号Frontiers Journals专题报道：https://mp.weixin.qq.com/s/QRYSrYy8FzMAgbbnN2c7mg).

[6]      Dong Li, Wande Zhang, Shuaibo Zhang, Wuding Sun, Jinfeng Zhao, Baomin Wang, Jingping Qu, Yuhan Zhou.* Palladium-catalyzed asymmetric trifluoromethylated allylic alkylation of pyrazolones enabled by α-(trifluoromethyl)alkenyl acetates. Org. Lett. 2021, 23(15), 5804-5808.

[7]      Chunxia Zhang, Dong Li, Yilong Zhao, Jinfeng Zhao, Jingping Qu, Yuhan Zhou.* Base-free Suzuki–Miyaura coupling of (Z)-trifluoromethyl alkenyl triflates: an efficient approach to α-trifluoromethyl arylenes. ChemistrySelect 2020, 5, 13099-13102.

[8]      Junyan Zhao, Xun Song, Dong Li, Jinfeng Zhao, Jingping Qu, Yuhan Zhou.* Intramolecular dehydrogenative coupling approach to 2-oxindoles using Fe(OAc)₂/NaI/Na₂S₂O₈. Eur. J. Org. Chem. 2020, 6392-6398.

[9]      Dong Li, Shujun Lv, Jingping Qu, Yuhan Zhou.* Oxidation of 4-aryl-1,1,1-trifluorobut-2-en-2-yl trifluoromethanesulfonates by 4-picoline-N-oxide: a novel approach to β-trifluoromethyl-α,β-enones. Synthesis 2020, 52, 1203-1210.

[10]   Yu Cao, Wuding Sun, Gen Luo, Yang Yu, Yuhan Zhou, Yanan Zhao, Jimin Yang, Y Luo. Mechanistic Insights into La-Catalyzed Amidation of Aldehyde with Amine. Org. Lett. 2020, 22(2), 705-708.

[11]   Yang Liu, Yuhan Zhou,* Dong Li, Han Chen, Jinfeng Zhao, Jingping Qu. Iron-catalyzed boration of cinnamyl carbonates: a highly stereoselective approach to cyclopropylboronates. Org. Chem. Front. 2019, 6, 983-988.

[12]   Han Chen, Sijia Sun, Haoying Xi, Kaifang Hu, Ning Zhang, Jingping Qu, Yuhan Zhou.* Catalytic oxidative conversion of aldehydes into nitriles using NH₃•H₂O/FeCl₂/NaI/Na₂S₂O₈: a practical approach to febuxostat. Tetrahedron Lett. 2019, 60, 1434-1436.

[13]   Yuhan Zhou, Chunxia Zhang, Yilong Zhao, Dong Li, Jinfeng Zhao, Zhaotian Wang, Jingping Qu. Base-promoted double-bond-migration/hydrolysis/isomerization of 4-aryl-1,1,1-trifluorobut-2-en-2-yl trifluoromethanesulfonates: a metal-free approach to β-trifluoromethyl ketones. Eur. J. Org. Chem. 2018, 6217-6222.

[14]   Dong Li, Yuhan Zhou*, Yilong Zhao, Chunxia Zhang, Jianzhe Li, Jinfeng Zhao, Jingping Qu. Synthesis of 2-trifluoromethyl-2-hydroxy-2H-chromenes via cyclization of (Z)-trifluoromethyl alkenyl triflates and salicylaldehydes. J. Fluorine Chem. 2018, 212, 122-129.

[15]   Yilong Zhao, Yuhan Zhou,* Chunxia Zhang, Dong Li, Puhua Sun, Jianzhe Li, Huan Wang, Jianhui Liu, Jingping Qu. Base-controlled regiodivergent azidation of trifluoromethyl alkenyl triflates: transition-metal-free access to CF₃-containing allyl azides and alkenyl azides. J. Org. Chem. 2018, 83(5), 2858-2868.

[16]   Yuhan Zhou,* Huan Wang, Yang Liu, Yilong Zhao, Chunxia Zhang, Jingping Qu. Iron-catalyzed boration of allylic alcohols with H₃BO₃ as an additive. Synth. Commun. 2018, 48(7), 795-801.

[17]   Yang Liu, Yuhan Zhou,* Yilong Zhao, Jingping Qu. Synthesis of gem-difluoroallylboronates via FeCl₂-catalyzed boration/β-fluorine elimination of trifluoromethyl alkenes. Org. Lett. 2017, 19(4), 946-949.

[18]   Yuhan Zhou,* Huan Wang, Yang Liu, Yilong Zhao, Chunxia Zhang and Jingping Qu. Iron-catalyzed boration of allylic esters: an efficient approach to allylic boronates. Org. Chem. Front. 2017, 4(8), 1580 - 1585.

[19]   Yilong Zhao, Yuhan Zhou,* Chunxia Zhang, Huan Wang, Jinfeng Zhao, Kun Jin, Jihong Liu, Jianhui Liu, Jingping Qu. Palladium-catalyzed geometrically selective hydrogenation of (Z)-trifluoromethyl alkenyl triflate: an efficient approach to (Z) or (E)-3,3,3-trifluoropropenyl derivatives. Org. Biomol. Chem. 2017, 15(27), 5693-5700. (Inside front cover, 2017 Hot Articles).

[20]   Yuhan Zhou,* Ling Li, Xiaoliang Dong, Yixin Zhang, Dawei Yang, Yang Liu, Jingping Qu.* Synthesis of diiron sulfur clusters containing thiolato-1,8-naphthalene imide ligand. Inorg. Chem. Commun. 2017, 80, 10-14.

[21]   Yuhan Zhou,* Changpeng Wu, Xiaoliang Dong, Jingping Qu. Synthesis of 6-trichloromethylphenanthridines by transition metal-free radical cyclization of 2-isocyanobiphenyls. J. Org. Chem. 2016, 81(12), 5202-5208.

[22]   Yilong Zhao, Yuhan Zhou,* Juan Liu, Dongmei Yang, Liang Tao, Yang Liu, Xiaoliang Dong, Jianhui Liu, Jingping Qu. Synthesis of (Z)-α-trifluoromethyl alkenyl triflate: a scaffold for diverse trifluoromethylated species. J. Org. Chem. 2016, 81(11), 4797-4806.

[23]   Yuhan Zhou,* Xiaoliang Dong, Yixin Zhang, Peng Tong, and Jingping Qu*. Highly selective fluorescence sensors for the fluoride anion based on carboxylate-bridged diiron complexes. Dalton Trans. 2016, 45, 6839-6846. (back cover)

[24]   Changpeng Wu, Yuhan Zhou,* Xiaoliang Dong, Jingping Qu. Synthesis of 6-(arylthio)phenanthridines by cyclization reaction of 2-isocyanobiphenyls with thiols. ARKIVOC 2016, (iii), 110-124.

[25]   Yang Liu, Yuhan Zhou,* Huan Wang and Jingping Qu. FeCl₂-catalyzed hydroboration of aryl alkenes with bis(pinacolato)diboron. RSC Adv. 2015, 5, 73705-73713.

[26]   Xiaoliang Dong, Litao Liu, Yuhan Zhou,* Jun Liu, Yixin Zhang, Yanhui Chen, and Jingping Qu.* Synthesis of carboxylate-bridged iron-thiolate clusters from alcohols/aldehydes or carboxylate salts. Dalton Trans. 2015, 44, 14952-14958.

[27]   Xiaoliang Dong, Yuhan Zhou,* Yuming Song, Jingping Qu. Anthracene-Fe³⁺ ensemble based turn-on fluorescent probes for selective detection of fluoride. J. Fluorine Chem. 2015, 178, 61-67.

[28]   Dongmei Yang, Yuhan Zhou,* Yuming Song, Jingping Qu. A practical synthesis of trifluoromethyl alkyl ketones. J. Fluorine Chem. 2015, 173, 6-11.

[29]   Yuhan Zhou,* Yuming Song, Yang Liu, Jingping Qu. A convenient one-pot preparation of spiro[fluorene-9,9’-xanthene]-3’,6’-diol derivatives. ARKIVOC 2015 (v), 99-109.

[30]   Weiguo Song, Liangjun Dong, Yuhan Zhou,* Yongqiang Fu, Wenfang Xu. Catalytic asymmetric synthesis of esomeprazole by a titanium complex with a hexaaza triphenolic macrocycle ligand. Synth. Commun., 2015, 45(1), 70-77.

[31]   Yuhan Zhou,* Dongmei Yang, Gen Luo, Yilong Zhao, Yi Luo,* Na Xue, Jingping Qu. Highly selective trifluoroacetic ester/ketone metathesis: an efficient approach to trifluoromethyl ketones and esters. Tetrahedron 2014, 70(31), 4668-4674.

[32]   Yuhan Zhou,* Guchao Gao, Yuming Song, Jingping Qu*. Enantioselective reduction of prochiral ketones with NaBH₄/Me₂SO₄/(S)-Me-CBS. Synth. Commun., 2014, 44(10), 1515-1520.

[33]   杨冬梅，周宇涵，* 常晴，赵一龙，曲景平. 三氟甲基烷基酮的生物活性及合成方法. 化学进展 2014, 26(6), 976-986.

[34]   Xiaoneng Cui, Jianzhang Zhao, Yuhan Zhou, Jie Ma, Yilong Zhao. Reversible photoswitching of triplet-triplet annihilation upconversion using dithienylethene photochromic switches. J. Am. Chem. Soc. 2014, 136, 9256-9259.

[35]   Dongmei Yang, Yuhan Zhou,* Na Xue, Jingping Qu.* Synthesis of trifluoromethyl ketones via tandem claisen condensation and retro-claisen C−C bond-cleavage reaction. J. Org. Chem. 2013, 78(8), 4171-4176. (“organic-chemistry.org”专题报道: J42-Y2013)

[36]   Jinfeng Zhao, Lei Wang, Yuhan Zhou,* Yixin Zhang, Nan Zhang, Chunmei Jia, Fengshuo Hu, Yanhui Chen, Baomin Wang, Jingping Qu.* Synthesis, structure and reactions of triply selenolate-bridged diiron complex [Cp*Fe(µ-SeMe)₃FeCp*]. Inorg. Chem. Commun. 2013, 29, 179-182.

[37]   Weiguo Song, Yuhan Zhou,* Yongqiang Fu, Wenfang Xu. Self-disproportionation of enantiomers of prazoles via achiral, gravity-driven silica gel column chromatography. Tetrahedron: Asymmetry 2013, 24(15-16), 909-912.

[38]   Yang Li, Ying Li, Baomin Wang, Yi Luo, Dawei Yang, Peng Tong, Jinfeng Zhao, Lun Luo, Yuhan Zhou, Si Chen, Fang Cheng, Jingping Qu. Ammonia formation by a thiolate-bridged diiron amide complex as a nitrogenase mimic. Nature Chem. 2013, 5(4), 320-326.

[39]   Jinfeng Zhao, Lei Wang, Yuhan Zhou, Yixin Zhang, Nan Zhang, Yanhui Chen, Jingping Qu. Synthesis and characterization of a thiolate-bridged diiron complex with two monocoordinated azido ligands: [Cp*Fe(μ-SMe)N₃]₂ (Cp* = η⁵-C₅Me₅). Chinese J. Struc. Chem. 2013, 32 (7), 1083-1087.

[40]   Guowei Wang, Baomin Wang, Shuai Qi, Jinfeng Zhao, Yuhan Zhou, Jingping Qu*. Highly enantio- and diastereoselective vinylogous aldol reaction by LiCl-assisted BINOL―titanium species，Org. Lett. 2012, 14, 2734-2737.

[41]   董晓亮，周宇涵*，徐珊珊，曲景平*. 5-芳甲氧基苯基吡唑衍生物的合成及除草活性. 有机化学, 2011, 31(7), 1020-1026.

[42]   赵金凤，窦海建，周宇涵，曲景平. (S,S)-TsDPEN-Ru催化不对称氢转移还原β-胺基酮及在度洛西汀合成中的应用. 高等学校化学学报，2011, 32 (10), 2331-2334.

[43]   Yuhan Zhou, Thomas Lecourt, Laurent Micouin. Direct synthesis of 1,4-disubstituted-5-alumino-1,2,3-triazoles by a copper-catalyzed cycloaddition of organic azides and mixed-aluminum acetylides. Angew. Chem. Int. Ed. 2010, 49(14), 2607-2610 (Synfacts 2010, 6, 0704).

[44]   Yuhan Zhou,* Na Xue, Guowei Wang, Jingping Qu. Synthesis, structure and herbicidal activity of substituted phenyl pyrazole derivatives. J. Chem. Res.2010, 34(12), 684-688.

[45]   Guowei Wang, Jinfeng Zhao, Yuhan Zhou, Baomin Wang, Jingping Qu. Mild and highly enantioselective vinylogous aldol reaction of brassard’s diene with aromatic aldehydes by combined Lewis acid catalyst. J. Org. Chem. 2010, 75(15), 5326-5329 （Synfacts 2010, 6, 1266）.

[46]   Yuhan Zhou,* Yanhui Chen, Weirong Miao, Jingping Qu. Synthesis, structures and herbicidal activity of isoxazole derivatives. J. Heterocyclic Chem. 2010, 47(6), 1310-1316.

[47]   Yinsong Tao, Yuhan Zhou, Jingping Qu, Masanobu Hidai. Highly efficient and regioselective allylic amination of allylic alcohols catalyzed by [Mo₃PdS₄] cluster. Tetrahedron Lett. 2010, 51, 1982-1984.

[48]   Na Xue, Yuhan Zhou,* Guowei Wang, Weirong Miao, Jingping Qu.* Syntheses and herbicidal activity of pyrazolyl benzoxazole derivatives. J. Heterocyclic Chem. 2010, 47(1): 15-21 (Top accessed papers from 2010).

[49]   Pingping Chen, Yanhui Chen, Yuhan Zhou, Ying Peng, Jingping Qu, Masanobu Hidai. Heterometallic cubane-type clusters [MMo₃S₄] (M = Au, Ag and Cu): synthesis, structures and electrochemical properties. Dalton Trans. 2010, 39, 5658 – 5663.

[50]   Yuhan Zhou, Thomas Lecourt, Laurent Micouin. Room temperature Lewis base-catalyzed alumination of terminal alkynes. Adv. Synth. Catal. 2009, 351(16): 2595-2598.

[51]   Yanhui Chen, Yuhan Zhou, Pingping Chen, Yinsong Tao, Yang Li, Jingping Qu. Nitrogenase model complexes [Cp*Fe(μ-SR¹)₂(μ-η²-R²N=NH)FeCp*] (R¹ = Me, Et; R² = Me, Ph; Cp* = η⁵-C₅Me₅): synthesis, structure, and catalytic N-N bond cleavage of hydrazines on diiron centers. J. Am. Chem. Soc. 2008, 130(46): 15250-15251 (JACS ^β Select issue 9).

[52]   Yuhan Zhou, Guchao Gao, Hui Li, Jingping Qu. A convenient method to reduce hydroxyl-substituted aromatic carboxylic acid with NaBH₄/Me₂SO₄/B(OMe)₃, Tetrahedron Lett. 2008, 49, 3260-3263.

[53]   Yanhui Chen, Yuhan Zhou, Jingping Qu. Synthesis and reactions of novel triply thiolate-bridged diiron complexes [Cp*Fe(µ₂-SR)₃FeCp*] (Cp*= η⁵-C₅Me₅; R = Et, Ph), Organometallics 2008, 27(4), 666–671.

专著

[1]      Yuhan Zhou*, Xiaoliang Dong, Jingping Qu. Synthesis, structure and herbicidal activity of pyrazole derivatives. in Daiki Kobayashi and Eito Watanabe Edit: Handbook on Herbicides: Biological Activity, Classification and Health & Environmental Implications (Chapter 13) USA: Nova Science Publishers, 2013, 263-276 (2013-12).

[2]      Serge Mignani, Yuhan Zhou, Thomas Lecourt, Laurent Micouin. Recent Developments in the Synthesis 1,4,5-Trisubstituted Triazoles. Topics in Heterocyclic Chemistry Vol. 28: Click Triazoles. (Edited by Janez Košmrlj.) Springer-Verlag Berlin Heidelberg: 2012, 185-232.

[3]      李和平，周宇涵，冯光柱，申艳敏，黄雪，刘云，袁超，何利霞. 含氟溴碘精细化学品. 北京：化学工业出版社，2010-09-01.（“十一五国家重点图书”）

[4]      李和平，冯光柱，魏文珑，孙建军，周宇涵，黄雪. 含氯精细化学品. 北京：化学工业出版社，2010-08-01. （“十一五国家重点图书”）

授权专利：

[1]      周宇涵，苗蔚荣. 取代苯基吡唑类除草剂. CN 1402979A，2003-3-19, 专利号：ZL02143654.1, 2005-12-28.

[2]      周宇涵，苗蔚荣. 四取代苯基噁唑烷酮类除草剂. CN 1280768A，2001-1-24, 专利号：ZL00126117.7, 2003-7-9.

[3]      周宇涵，苗蔚荣. 取代苯基异噁唑类除草剂. CN1939127, 2007-4-4, 专利号：ZL200510119757.3, 2008-8-13.

[4]      周宇涵，曲景平，薛娜，王国伟. 一种除草剂及其制备方法. 专利号：200810011338.1，2012-2-29. CN101270117, 2008-9-24.

[5]      周宇涵，曲景平，薛娜，王国伟. 苯并噁唑类除草剂及其制备方法. 专利号：200810011437.x，2011-2-2. CN101279972, 2008-10-8.

[6]      曲景平，李阳，周宇涵，杨大伟，李莹，童鹏，赵金凤. 邻苯二硫酚基和二氮烯架桥的双核铁配合物、其制备方法及应用. 专利号：201210006012.6, 2014.6.25. CN 102558244, 2012-7-11.

[7]      曲景平，李阳，周宇涵，杨大伟，李莹，童鹏，赵金凤. 邻苯二硫酚基和氨/胺架桥的双核铁配合物、其制备方法及应用. 专利号：201210024391.1, 2014.8.27. CN 102603808, 2012-7-25.

[8]      曲景平，赵金凤，周宇涵，李阳，贾春媚，王磊，陈延辉. 烃硫基和氮/氨基架桥的双核铁配合物、其制备方法及应用. 专利号：201210065151.6, 2014-8-27. CN 102617650A, 2012.8.1.

[9]      周宇涵，曲景平，杨冬梅，薛娜. 一种制备全氟烷基烷基酮化合物的方法. 专利号：201210411390.2，2015-2-25. CN 102924201A, 2013.2.13.

[10]   宋伟国，周宇涵，付永强，董良军，徐文方. 一种拉唑类化合物单一对映体的分离方法. 专利号：201310118349.0，2015-6-17. CN 103193572A, 2013-07-10.

[11]   宋伟国，付永强，孙晓明，董良军，高东圣，周宇涵，夏艳，王伟，吕伟香，田梅. 一种用于埃索美拉唑不对称合成的催化剂. 专利号: 201410286767.5, 2016.7.6. CN104030997A, 2014.09.10.

[12]   周宇涵，曲景平，董晓亮. 一类以蒽为母体的双功能荧光探针、制备方法及应用. 专利号: 201510181059.X, 2016.12.7. CN104788344A, 2015.7.22.

[13]   周宇涵，曲景平，柳阳，王欢.基于铁催化制备烷基硼酸酯化合物的方法.专利号:201510292951.5, 2017.6.27，申请日：2015.6.1. CN104892655A, 2015.9.9.

[14]   周宇涵，曲景平，董晓亮. 一类羧酸根桥联双核铁配合物荧光探针、制备方法及应用. 专利号: 201510561049.9, 2017.10.24. CN105085581A, 2015.11.25.

[15]   董良军，周宇涵，高东圣，王福洲，褚亚飞，吕伟香，李书涛，杨磊，宋伟国. 一种适用于工业化生产的右兰索拉唑的处理方法. 专利号：201510964214.5，2017.11.28，申请日期：2015.12.20.

[16]   周宇涵，曲景平，柳阳，赵一龙. 一种二氟烯丙基硼酸酯的制备方法及其应用. 专利号: 201610635012.0, 2018.3.13，申请日期：2016.8.4.

[17]   周宇涵，曲景平，吴昌朋，董晓亮. 一类6-三氯甲基菲啶类化合物及其制备方法和应用. 专利号：ZL 201610294227.0，2018.7.13，申请日期：2016.5.5. CN105859620B, 2016.8.17.

[18]   褚亚飞，周宇涵，杨磊，高东圣，董良军，王福洲，王洪明，侯俊杰，宋伟国. 一种埃索美拉唑及其盐的制备方法. 专利号：ZL201510981328.0, 2018.06.01. CN105669649A, 2016.6.15.

[19]   Yuhan Zhou, Jingping Qu, Xiaoliang Dong. Carboxylate-bridged binuclear iron-sulfur clusters fluorescent probe preparation method and application thereof. JP 2017-558380, 2018.12.14.

[20]   Yuhan Zhou, Jingping Qu, Xiaoliang Dong. Carboxylate-bridged binuclear iron-sulfur clusters fluorescent probe preparation method and application thereof. US 10352917B2, 申请日：2017.1.19；授权：2019.7.16.

[21]   周宇涵，曲景平，赵一龙，张成海，奚灏瀛，董述祥，范文霞. 一种1-芳基-3-叠氮基-4，4，4-三氟-1-丁烯化合物的制备方法. ZL201710526164.1, CN107382769B, 2019.8.20, 申请日期：2017.6.30.

[22] Yuhan Zhou, Jingping Qu, Yang Liu, Yilong Zhao. Method for preparing difluoroallylboronate and application thereof. US 10494383B2, 申请日：2017.6.23；授权：2019.12.3.

[23] 周宇涵，曲景平，赵一龙，刘建辉. 一种2-(2,2,2-三氟乙基)-3-芳基-2H-氮杂丙烯啶化合物的制备方法. ZL201710707321.9，2020.4.14，申请日期：2017.8.17. CN107501153B, 2020.4.14.

[24] 周宇涵，曲景平，柳阳. 一种基于铁催化制备环丙基硼酸酯化合物的方法. 专利号: 201810235802.9, 2020.6.2，申请日期：2018.3.21. CN108299486A, 2018.7.20.

[25] 周宇涵，曲景平，张春霞，赵一龙，李栋. 一种1-芳基-4,4,4-三氟-1-丁酮化合物的制备方法. 专利号: ZL201810737787.8，2020.6.2，申请日期：2018.7.6. CN108707067A, 2018.10.26.

[26] 周宇涵，曲景平，张春霞，赵一龙，李栋. 胰高血糖素受体拮抗剂中间体的制备方法.专利号: 201810738529.1, 2020.4.28，申请日期：2018.7.6. CN108727157A, 2018.11.2.

[27] 周宇涵，李栋，吕树均，曲景平. 一种(E)-1-芳基-4,4,4-三氟丁-2-烯-1-酮化合物的制备方法. 专利号：ZL201911115148.9，2020.9.29，申请日期：2019.11.14.

[28] 周宇涵，曲景平，陈晗，奚灏瀛，张成海. 一种非布司他及其中间体的合成方法. 申请号: 201811616474.3, 2021.5.7,申请日：2018.12.28. CN109503512A, 2019.3.22.

[29] 周宇涵，李栋，王保民，曲景平，冯芮茂，奚灏瀛，张成海. 一种含有三氟甲基的吡唑啉酮类化合物制备方法. 专利号: ZL202110772635.3, 2022.6.10, 申请日：2021.7.8. CN113354586A，2021.9.7.

[30] 周宇涵，廖苹，曲景平. 糖尿病肾病药物艾莎利酮的制备方法. 专利号: ZL202210062059.8，2024.6.14，申请日：2022.1.19. CN114456098A，2022.5.10.