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Indexed by:期刊论文

Date of Publication:2022-06-28

Journal:过程工程学报

Volume:12

Issue:6

Page Number:996-1001

ISSN No.:1009-606X

Abstract:A substrate feeding strategy was studied in the fed-batch fermentation
   of 1,3-propanediol by Klebsiella pneumoniae, which was distinctively
   coupled with cell growth and metabolism using glycerol as substrate. The
   functional relationship between substrate consumption, biomass and
   alkaline consumption was established by analysis of the cell growth
   kinetics during logarithmic growth and stationary phase, respectively.
   The fed-batch on-line experimental results showed that the glycerol
   concentration was controlled at 202 g/L, and the final 1,3-propanediol
   concentration reached 80.3 and 78.8 g/L, which increased 25.0 and 23.5
   g/L compared with that of manual feeding-back strategy.

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