个人信息Personal Information
教授
博士生导师
硕士生导师
主要任职:Director, State Key laboratory of Fine Chemicals
其他任职:精细化工国家重点实验室主任、国务院学科评议组成员
性别:男
毕业院校:大连理工大学
学位:博士
所在单位:化工学院
学科:应用化学. 精细化工. 化学生物学
办公地点:大连理工大学精细化工国家重点实验室
西部校区化工实验楼F-202#
http://peng-group.dlut.edu.cn/
联系方式:大连理工大学精细化工国家重点实验室 西部校区化工实验楼F-202 辽宁省大连市高新区凌工路2号,大连116024 Tel: 0411-84986306; Fax: 0411-84986292;课题组网址:http://peng-group.dlut.edu.cn/
电子邮箱:pengxj@dlut.edu.cn
Inhibiting proton interference in PET chemosensors by tuning the HOMO energy of fluorophores
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论文类型:期刊论文
发表时间:2018-04-15
发表刊物:SENSORS AND ACTUATORS B-CHEMICAL
收录刊物:SCIE、EI
卷号:259
页面范围:626-632
ISSN号:0925-4005
关键字:Sensor; Cell; Fluorescence; Electron transfer; Free energy
摘要:Fluorescent chemosensors are widely used in chemical engineering, bio-engineering, medical engineering, and environmental engineering. A lot of the chemosensors are based on photo-induced electron transfer (PET) process. In complicated practical systems, the proton is always the most serious interference factor. Herein a new method is proposed for PET chemosensor design to overcome the proton interference: to tune the Delta G of the electron transfer process by introducing different substituents of the sensor molecules. Chemosensors for Zn2+ detection are demonstrated. When the highest occupied molecular orbital (HOMO) energy levels of the fluorophores (4-substituted 1, 8-naphthalimide) are lower than the HOMO energy level of protonated receptor (dipicolylamine-H+), the fluorescence responding to Zn2+ ions is not influenced by pH, meanwhile, the chemosensors can work in acidic media with pH below the pKa values. This should reveal a new criterion for designing of PET based chemosensors for selectivity improvement. (C) 2017 Elsevier B.V. All rights reserved.