个人信息Personal Information
教授
博士生导师
硕士生导师
主要任职:Director, State Key laboratory of Fine Chemicals
其他任职:精细化工国家重点实验室主任、国务院学科评议组成员
性别:男
毕业院校:大连理工大学
学位:博士
所在单位:化工学院
学科:应用化学. 精细化工. 化学生物学
办公地点:大连理工大学精细化工国家重点实验室
西部校区化工实验楼F-202#
http://peng-group.dlut.edu.cn/
联系方式:大连理工大学精细化工国家重点实验室 西部校区化工实验楼F-202 辽宁省大连市高新区凌工路2号,大连116024 Tel: 0411-84986306; Fax: 0411-84986292;课题组网址:http://peng-group.dlut.edu.cn/
电子邮箱:pengxj@dlut.edu.cn
Syntheses of BODIPY-incorporated polymer nanoparticles with strong fluorescence and water compatibility
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论文类型:期刊论文
发表时间:2021-04-12
发表刊物:EUROPEAN POLYMER JOURNAL
卷号:141
ISSN号:0014-3057
关键字:BODIPY dyes; Fluorescent labeling; Precipitation polymerization; Polymer nanoparticle; Necklace-like structure
摘要:Borondipyrromethene (BODIPY) dyes have attracted enormous interest due to their excellent photo-physical and chemical properties. However, the strong hydrophobic nature of the dyes limits their applications in water based biological and medical samples. In this work, BODIPY derivatives bearing vinyl group were synthesized and polymerized to obtain high dispersible nanoparticles. The BODIPY monomers were synthesized via esterification of their phenol groups with acryloyl chlorides and fully characterized by NMR, MS, UV-vis, and fluorescence spectroscopies. BODIPY fluorescent polymer nanoparticles were prepared using precipitation polymerization of the BODIPY monomers with methacrylic acid (MAA) in the presence of cross-linkers and characterized in respect to spectroscopic property, polymer morphology and particles size distribution. It was found that the type of cross-linker and amount of solvent have significant effect on particles size and morphology. A prominent necklace-like structure that enabled the polymer nanoparticles to have a good dispersibility could be obtained by using trimethylolpropane trimethacrylate/divinylbenzene (TRIM/DVB) as the cross-linker. Moreover, the BODIPY based polymers exhibited much stronger fluorescence than BODIPY monomer in aqueous solution, especially with the smaller nanoparticles. The fluorescent polymer nanoparticle preparation proposed in this study can be a good choice for addressing the limitation of hydrophobic BODIPY dyes applications in the water-based biomedical media.